Han Joo Cho1, Jaemin Kim2, Seung Kwan Nah2, Jihyun Lee2, Chul Gu Kim2, Jong Woo Kim2. 1. Kim's Eye Hospital, Konyang University College of Medicine, 156, 4ga, Yeongdeungpo-dong, Yeongdeungpo-gu, Seoul, South Korea. chojoo@kimeye.com. 2. Kim's Eye Hospital, Konyang University College of Medicine, 156, 4ga, Yeongdeungpo-dong, Yeongdeungpo-gu, Seoul, South Korea.
Abstract
PURPOSE: To evaluate morphologic changes of choroidal neovascularization (CNV) on optical coherence tomography angiography (OCTA) during the nonexudative period and to correlate the features and timing of recurrence in neovascular age-related macular degeneration. (AMD). METHODS: Two hundred thirty-eight eyes with type 1 CNV were retrospectively reviewed. For cases with exudative recurrence, OCTA images were tracked for analysis between the recurrences. Qualitative parameters of morphologic changes of CNV on OCTA, including tiny branching vessels, anastomotic loops, peripheral vascular arcade, and perilesional halo, were correlated with the features of exudative recurrence. RESULTS: Exudative recurrence was identified in 163 cases, and among them, nonexudative morphological changes in CNV were identified using OCTA in 45 cases. For the cases with nonexudative changes on OCTA, exudative recurrence eventually developed within 0.5-3.5 months (mean, 2.3 ± 2.0 months) after identifying morphologic changes OCTA. The following changes in CNV were revealed on OCTA: tiny branching vessels in 53.3% (24/45) of cases, anastomotic loops in 40.0% (18/45), peripheral vascular arcades in 44.4% (20/45), and perilesional halo in 35.6% (16/45). Among the morphologic parameters, development of tiny branching vessels was significantly associated with early exudative recurrence (1.5 ± 1.2 months, p = 0.019), higher incidence of intraretinal fluid (IRF) (p = 0.016), and subretinal or subretinal pigment epithelial hemorrhage (p = 0.023) at recurrence, compared with other morphologic changes. CONCLUSION: Development of tiny branching vessels of CNV on OCTA during the nonexudative period was associated with early exudative recurrence, including IRF or hemorrhage. Identifying the nonexudative changes of CNV on OCTA might predict exudative recurrence and provide additional parameters for monitoring neovascular AMD.
PURPOSE: To evaluate morphologic changes of choroidal neovascularization (CNV) on optical coherence tomography angiography (OCTA) during the nonexudative period and to correlate the features and timing of recurrence in neovascular age-related macular degeneration. (AMD). METHODS: Two hundred thirty-eight eyes with type 1 CNV were retrospectively reviewed. For cases with exudative recurrence, OCTA images were tracked for analysis between the recurrences. Qualitative parameters of morphologic changes of CNV on OCTA, including tiny branching vessels, anastomotic loops, peripheral vascular arcade, and perilesional halo, were correlated with the features of exudative recurrence. RESULTS: Exudative recurrence was identified in 163 cases, and among them, nonexudative morphological changes in CNV were identified using OCTA in 45 cases. For the cases with nonexudative changes on OCTA, exudative recurrence eventually developed within 0.5-3.5 months (mean, 2.3 ± 2.0 months) after identifying morphologic changes OCTA. The following changes in CNV were revealed on OCTA: tiny branching vessels in 53.3% (24/45) of cases, anastomotic loops in 40.0% (18/45), peripheral vascular arcades in 44.4% (20/45), and perilesional halo in 35.6% (16/45). Among the morphologic parameters, development of tiny branching vessels was significantly associated with early exudative recurrence (1.5 ± 1.2 months, p = 0.019), higher incidence of intraretinal fluid (IRF) (p = 0.016), and subretinal or subretinal pigment epithelial hemorrhage (p = 0.023) at recurrence, compared with other morphologic changes. CONCLUSION: Development of tiny branching vessels of CNV on OCTA during the nonexudative period was associated with early exudative recurrence, including IRF or hemorrhage. Identifying the nonexudative changes of CNV on OCTA might predict exudative recurrence and provide additional parameters for monitoring neovascular AMD.
Authors: Hemal Mehta; Adnan Tufail; Vincent Daien; Aaron Y Lee; Vuong Nguyen; Mehmet Ozturk; Daniel Barthelmes; Mark C Gillies Journal: Prog Retin Eye Res Date: 2018-01-02 Impact factor: 21.198
Authors: Richard F Spaide; James G Fujimoto; Nadia K Waheed; Srinivas R Sadda; Giovanni Staurenghi Journal: Prog Retin Eye Res Date: 2017-12-08 Impact factor: 21.198
Authors: Yali Jia; Steven T Bailey; David J Wilson; Ou Tan; Michael L Klein; Christina J Flaxel; Benjamin Potsaid; Jonathan J Liu; Chen D Lu; Martin F Kraus; James G Fujimoto; David Huang Journal: Ophthalmology Date: 2014-03-27 Impact factor: 12.079
Authors: Florence Coscas; Marco Lupidi; Jean François Boulet; Alexandre Sellam; Diogo Cabral; Rita Serra; Catherine Français; Eric H Souied; Gabriel Coscas Journal: Br J Ophthalmol Date: 2018-11-22 Impact factor: 4.638
Authors: Krishnappa C Madhusudhana; Aaron Y Lee; Pearse A Keane; Usha Chakravarthy; Robert L Johnston; Catherine A Egan; Dawn Sim; Javier Zarranz-Ventura; Adnan Tufail; Martin McKibbin Journal: Br J Ophthalmol Date: 2016-03-30 Impact factor: 4.638