Guangjun Shao1, Chunru Xu2,3,4, Jikai Liu5, Xuesong Li2,3,4, Luchao Li5, Xiaofeng Li5, Xiaoqing Zhang2,3,4, Yidong Fan5, Liqun Zhou2,3,4. 1. Department of Urology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China, shgj2004@163.com. 2. Department of Urology, Peking University First Hospital, Beijing, China. 3. Institute of Urology, Peking University, Beijing, China. 4. National Urological Cancer Center, Beijing, China. 5. Department of Urology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Abstract
OBJECTIVE: The aim of this study was to improve understanding the clinical, pathologic, and prognostic features of urachal carcinoma (UrC), a retrospectively descriptive study was done in 2 clinical centers. METHODS: After excluding the 2 missed patients, the clinical and pathological data of 59 patients with UrC, who were diagnosed or treated at 2 clinical centers between 1986 and 2019, was retrospectively analyzed. SPSS 22.0 (IBM) and GraphPad Prism 8.0.1 were used for statistics and data visualization. Survival data were analyzed by the Kaplan-Meier method and Log-rank tests. Cox proportional hazards regression were performed for find risk factors on predicting the prognosis. RESULTS: Of all 59 patients, 47 were male and 12 were female. The median age at diagnosis was 51.6 years (range: 22-84 years). Gross hematuria was the most common symptom (79.66%). The majority of urachal neoplasms were adenocarcinomas (94.92%). Forty-two patients (72.41%) underwent extended partial cystectomy with en bloc resection of the entire urachus. The mean follow-up was 52 months (3-277 months). Median overall survival was 52.8 months (4-93 months). The 3-year cancer-specific survival (CSS) rate and 5-year CSS rate were 69.1% and 61.2%. There was no significant difference among localized T stage, tumor histologic grade and surgical procedures in determining prognosis by survival analyze. While patients with high-risk TNM stage (local abdominal metastasis, lymph node metastasis, or distant metastasis) (p = 0.003) and positive surgical margin (p < 0.001) had significantly worse prognosis. CONCLUSIONS: The results indicate that high-risk TNM stage and positive surgical margin are risk predictors of prognosis. Localized T stage, histologic grade, and surgical procedure cause no significant effect on patient prognosis. The extended partial cystectomy is the recommended surgical approach for patients with UrC. Active multimodal treatments may improve the survival of patients with recurrent and metastatic disease.
OBJECTIVE: The aim of this study was to improve understanding the clinical, pathologic, and prognostic features of urachal carcinoma (UrC), a retrospectively descriptive study was done in 2 clinical centers. METHODS: After excluding the 2 missed patients, the clinical and pathological data of 59 patients with UrC, who were diagnosed or treated at 2 clinical centers between 1986 and 2019, was retrospectively analyzed. SPSS 22.0 (IBM) and GraphPad Prism 8.0.1 were used for statistics and data visualization. Survival data were analyzed by the Kaplan-Meier method and Log-rank tests. Cox proportional hazards regression were performed for find risk factors on predicting the prognosis. RESULTS: Of all 59 patients, 47 were male and 12 were female. The median age at diagnosis was 51.6 years (range: 22-84 years). Gross hematuria was the most common symptom (79.66%). The majority of urachal neoplasms were adenocarcinomas (94.92%). Forty-two patients (72.41%) underwent extended partial cystectomy with en bloc resection of the entire urachus. The mean follow-up was 52 months (3-277 months). Median overall survival was 52.8 months (4-93 months). The 3-year cancer-specific survival (CSS) rate and 5-year CSS rate were 69.1% and 61.2%. There was no significant difference among localized T stage, tumor histologic grade and surgical procedures in determining prognosis by survival analyze. While patients with high-risk TNM stage (local abdominal metastasis, lymph node metastasis, or distant metastasis) (p = 0.003) and positive surgical margin (p < 0.001) had significantly worse prognosis. CONCLUSIONS: The results indicate that high-risk TNM stage and positive surgical margin are risk predictors of prognosis. Localized T stage, histologic grade, and surgical procedure cause no significant effect on patient prognosis. The extended partial cystectomy is the recommended surgical approach for patients with UrC. Active multimodal treatments may improve the survival of patients with recurrent and metastatic disease.
Authors: Mélanie Claps; Marco Stellato; Emma Zattarin; Alessia Mennitto; Pierangela Sepe; Valentina Guadalupi; Roberta Mennitto; Filippo G M de Braud; Elena Verzoni; Giuseppe Procopio Journal: Curr Oncol Rep Date: 2020-01-27 Impact factor: 5.075
Authors: Ana Collazo-Lorduy; Mireia Castillo-Martin; Li Wang; Vaibhav Patel; Gopa Iyer; Emmet Jordan; Hikmat Al-Ahmadie; Issa Leonard; William K Oh; Jun Zhu; Russell B McBride; Carlos Cordon-Cardo; David B Solit; John P Sfakianos; Matthew D Galsky Journal: Eur Urol Date: 2016-05-10 Impact factor: 20.096
Authors: Sebastian Thiem; Thomas Herold; Ulrich Krafft; Felix Bremmer; Yuri Tolkach; Attila M Szász; Joerg Kriegsmann; Nadine T Gaisa; Christian Niedworok; Tibor Szarvas; Henning Reis Journal: Pathol Int Date: 2017-10-19 Impact factor: 2.534
Authors: Anuradha Gopalan; David S Sharp; Samson W Fine; Satish K Tickoo; Harry W Herr; Victor E Reuter; Semra Olgac Journal: Am J Surg Pathol Date: 2009-05 Impact factor: 6.394
Authors: Orsolya Módos; Henning Reis; Christian Niedworok; Herbert Rübben; Attila Szendröi; Marcell A Szász; József Tímár; Kornélia Baghy; Ilona Kovalszky; Tomasz Golabek; Piotr Chlosta; Krzysztof Okon; Benoit Peyronnet; Romain Mathieu; Shahrokh F Shariat; Péter Hollósi; Péter Nyirády; Tibor Szarvas Journal: Oncotarget Date: 2016-06-28
Authors: Nikolett Nagy; Henning Reis; Boris Hadaschik; Christian Niedworok; Orsolya Módos; Attila Szendrői; Krisztina Bíró; Thomas Hager; Thomas Herold; Jason Ablat; Peter C Black; Krzysztof Okon; Yuri Tolkach; Anita Csizmarik; Csilla Oláh; David Keresztes; Felix Bremmer; Nadine T Gaisa; Joerg Kriegsmann; Ilona Kovalszky; András Kiss; József Tímár; Marcell A Szász; Michael Rink; Margit Fisch; Péter Nyirády; Tibor Szarvas Journal: Pathol Oncol Res Date: 2020-08-04 Impact factor: 3.201
Authors: Davide Loizzo; Savio D Pandolfo; Fabio Crocerossa; Georgi Guruli; Matteo Ferro; Asit K Paul; Ciro Imbimbo; Giuseppe Lucarelli; Pasquale Ditonno; Riccardo Autorino Journal: Eur Urol Open Sci Date: 2022-03-14