Literature DB >> 34515152

Biomarker-Based Management of AKI: Fact or Fantasy?

Marlies Ostermann1, Emma Karsten2, Nuttha Lumlertgul1,3,4.   

Abstract

New biomarkers for acute kidney injury (AKI) have improved our understanding of the etiology and pathogenesis of AKI. Depending on their origin, function, and kinetic profile, biomarkers have a role in screening, diagnosis, prognostication, and monitoring of AKI. This offers opportunities to improve the management of AKI, but concerns and limitations remain. In this review, we summarize the current role of new AKI biomarkers in the management of AKI and outline some of the ongoing limitations and challenges.
© 2021 The Author(s) Published by S. Karger AG, Basel.

Entities:  

Keywords:  Acute kidney injury; Biomarkers

Mesh：

Substances：

Year:  2021        PMID： 34515152      PMCID： PMC9216309          DOI： 10.1159/000518365

Source DB:  PubMed          Journal:  Nephron        ISSN： 1660-8151            Impact factor:   3.457


  19 in total

1.  Renal biomarker qualification submission: a dialog between the FDA-EMEA and Predictive Safety Testing Consortium.

Authors:  Frank Dieterle; Frank Sistare; Federico Goodsaid; Marisa Papaluca; Josef S Ozer; Craig P Webb; William Baer; Anthony Senagore; Matthew J Schipper; Jacky Vonderscher; Stefan Sultana; David L Gerhold; Jonathan A Phillips; Gérard Maurer; Kevin Carl; David Laurie; Ernie Harpur; Manisha Sonee; Daniela Ennulat; Dan Holder; Dina Andrews-Cleavenger; Yi-Zhong Gu; Karol L Thompson; Peter L Goering; Jean-Marc Vidal; Eric Abadie; Romaldas Maciulaitis; David Jacobson-Kram; Albert F Defelice; Elizabeth A Hausner; Melanie Blank; Aliza Thompson; Patricia Harlow; Douglas Throckmorton; Shen Xiao; Nancy Xu; William Taylor; Spiros Vamvakas; Bruno Flamion; Beatriz Silva Lima; Peter Kasper; Markku Pasanen; Krishna Prasad; Sean Troth; Denise Bounous; Denise Robinson-Gravatt; Graham Betton; Myrtle A Davis; Jackie Akunda; James Eric McDuffie; Laura Suter; Leslie Obert; Magalie Guffroy; Mark Pinches; Supriya Jayadev; Eric A Blomme; Sven A Beushausen; Valérie G Barlow; Nathaniel Collins; Jeff Waring; David Honor; Sandra Snook; Jinhe Lee; Phil Rossi; Elizabeth Walker; William Mattes
Journal:  Nat Biotechnol       Date:  2010-05-10       Impact factor: 54.908

2.  Biomarkers predict progression of acute kidney injury after cardiac surgery.

Authors:  Jay L Koyner; Amit X Garg; Steven G Coca; Kyaw Sint; Heather Thiessen-Philbrook; Uptal D Patel; Michael G Shlipak; Chirag R Parikh
Journal:  J Am Soc Nephrol       Date:  2012-03-01       Impact factor: 10.121

3.  Diagnostic and prognostic stratification in the emergency department using urinary biomarkers of nephron damage: a multicenter prospective cohort study.

Authors:  Thomas L Nickolas; Kai M Schmidt-Ott; Pietro Canetta; Catherine Forster; Eugenia Singer; Meghan Sise; Antje Elger; Omar Maarouf; David Antonio Sola-Del Valle; Matthew O'Rourke; Evan Sherman; Peter Lee; Abdallah Geara; Philip Imus; Achuta Guddati; Allison Polland; Wasiq Rahman; Saban Elitok; Nasir Malik; James Giglio; Suzanne El-Sayegh; Prasad Devarajan; Sudarshan Hebbar; Subodh J Saggi; Barry Hahn; Ralph Kettritz; Friedrich C Luft; Jonathan Barasch
Journal:  J Am Coll Cardiol       Date:  2012-01-17       Impact factor: 24.094

4.  Assessment of KDIGO definitions in patients with histopathologic evidence of acute renal disease.

Authors:  Rong Chu; Cui Li; Suxia Wang; Wanzhong Zou; Gang Liu; Li Yang
Journal:  Clin J Am Soc Nephrol       Date:  2014-05-01       Impact factor: 8.237

5.  Tissue Inhibitor Metalloproteinase-2 (TIMP-2)⋅IGF-Binding Protein-7 (IGFBP7) Levels Are Associated with Adverse Long-Term Outcomes in Patients with AKI.

Authors:  Jay L Koyner; Andrew D Shaw; Lakhmir S Chawla; Eric A J Hoste; Azra Bihorac; Kianoush Kashani; Michael Haase; Jing Shi; John A Kellum
Journal:  J Am Soc Nephrol       Date:  2014-12-22       Impact factor: 10.121

6.  The Japanese Clinical Practice Guideline for acute kidney injury 2016.

Authors:  Kent Doi; Osamu Nishida; Takashi Shigematsu; Tomohito Sadahiro; Noritomo Itami; Kunitoshi Iseki; Yukio Yuzawa; Hirokazu Okada; Daisuke Koya; Hideyasu Kiyomoto; Yugo Shibagaki; Kenichi Matsuda; Akihiko Kato; Terumasa Hayashi; Tomonari Ogawa; Tatsuo Tsukamoto; Eisei Noiri; Shigeo Negi; Koichi Kamei; Hirotsugu Kitayama; Naoki Kashihara; Toshiki Moriyama; Yoshio Terada
Journal:  J Intensive Care       Date:  2018-08-13

7.  Worsening Renal Function in Patients With Acute Heart Failure Undergoing Aggressive Diuresis Is Not Associated With Tubular Injury.

Authors:  Tariq Ahmad; Keyanna Jackson; Veena S Rao; W H Wilson Tang; Meredith A Brisco-Bacik; Horng H Chen; G Michael Felker; Adrian F Hernandez; Christopher M O'Connor; Venkata S Sabbisetti; Joseph V Bonventre; F Perry Wilson; Steven G Coca; Jeffrey M Testani
Journal:  Circulation       Date:  2018-01-19       Impact factor: 29.690

8.  Recommendations on Acute Kidney Injury Biomarkers From the Acute Disease Quality Initiative Consensus Conference: A Consensus Statement.

Authors:  Marlies Ostermann; Alexander Zarbock; Stuart Goldstein; Kianoush Kashani; Etienne Macedo; Raghavan Murugan; Max Bell; Lui Forni; Louis Guzzi; Michael Joannidis; Sandra L Kane-Gill; Mathieu Legrand; Ravindra Mehta; Patrick T Murray; Peter Pickkers; Mario Plebani; John Prowle; Zaccaria Ricci; Thomas Rimmelé; Mitchell Rosner; Andrew D Shaw; John A Kellum; Claudio Ronco
Journal:  JAMA Netw Open       Date:  2020-10-01

9.  Prevention of cardiac surgery-associated AKI by implementing the KDIGO guidelines in high risk patients identified by biomarkers: the PrevAKI randomized controlled trial.

Authors:  Melanie Meersch; Christoph Schmidt; Andreas Hoffmeier; Hugo Van Aken; Carola Wempe; Joachim Gerss; Alexander Zarbock
Journal:  Intensive Care Med       Date:  2017-01-21       Impact factor: 17.440

10.  Proenkephalin A 119-159 (Penkid) Is an Early Biomarker of Septic Acute Kidney Injury: The Kidney in Sepsis and Septic Shock (Kid-SSS) Study.

Authors:  Alexa Hollinger; Xavier Wittebole; Bruno François; Peter Pickkers; Massimo Antonelli; Etienne Gayat; Benjamin Glenn Chousterman; Jean-Baptiste Lascarrou; Thierry Dugernier; Salvatore Di Somma; Joachim Struck; Andreas Bergmann; Albertus Beishuizen; Jean-Michel Constantin; Charles Damoisel; Nicolas Deye; Stéphane Gaudry; Vincent Huberlant; Gernot Marx; Emanuelle Mercier; Haikel Oueslati; Oliver Hartmann; Romain Sonneville; Pierre-François Laterre; Alexandre Mebazaa; Matthieu Legrand
Journal:  Kidney Int Rep       Date:  2018-08-22
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  1 in total

Review 1.  Acute Kidney Injury: Biomarker-Guided Diagnosis and Management.

Authors:  Soo-Young Yoon; Jin-Sug Kim; Kyung-Hwan Jeong; Su-Kang Kim
Journal:  Medicina (Kaunas)       Date:  2022-02-23       Impact factor: 2.430
  1 in total

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