Literature DB >> 34507931

The protective effect of previous COVID-19 infection in a high-prevalence hospital setting.

Favian Narrainen1, Madeleine Shakeshaft2, Hibo Asad3, Abigail Holborow2, Ian Blyth2, Brendan Healy2.   

Abstract

OBJECTIVE: To assess the protective effect of previous COVID-19 infection for healthcare workers in a high-prevalence setting.
METHOD: The COVID-19 antibody and PCR results of 538 healthcare workers on wards with COVID-19 outbreaks from 1 March 2020 to 31 July 2020 were evaluated. Infection rates of the 'previously infected' and 'no evidence of previous infection' groups were compared during second-wave outbreaks between 29 September 2020 and 20 November 2020.
RESULTS: One out of 115 individuals previously infected developed infection compared with 104 out of 423 individuals with no evidence of previous infection. Attack rates in staff previously infected was reduced significantly from 24.59% to 0.87% (odds ratio 0.027, 95% CI 0.004-0.195, p<0.001) when compared to the 'no evidence of previous infection' group with the same exposure risk.
CONCLUSION: Prior SARS-CoV-2 infection offers significant protection against reinfection and this protection lasts 4 months for the majority of individuals. © Royal College of Physicians 2021. All rights reserved.

Entities:  

Keywords:  COVID-19; SARS-CoV-2; antibodies; health personnel; reinfection

Mesh：

Year:  2021        PMID： 34507931      PMCID： PMC8439501          DOI： 10.7861/clinmed.2021-0225

Source DB:  PubMed          Journal:  Clin Med (Lond)        ISSN： 1470-2118            Impact factor:   5.410


  16 in total

1.  A case of COVID-19 reinfection in the UK.

Authors:  Jack West; Serenydd Everden; Nikitas Nikitas
Journal:  Clin Med (Lond)       Date:  2020-12-10       Impact factor: 2.659

2.  Symptomatic Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reinfection by a Phylogenetically Distinct Strain.

Authors:  Jan Van Elslande; Pieter Vermeersch; Kris Vandervoort; Tony Wawina-Bokalanga; Bert Vanmechelen; Elke Wollants; Lies Laenen; Emmanuel André; Marc Van Ranst; Katrien Lagrou; Piet Maes
Journal:  Clin Infect Dis       Date:  2021-07-15       Impact factor: 9.079

3.  Interpreting a covid-19 test result.

Authors:  Jessica Watson; Penny F Whiting; John E Brush
Journal:  BMJ       Date:  2020-05-12

4.  The time course of the immune response to experimental coronavirus infection of man.

Authors:  K A Callow; H F Parry; M Sergeant; D A Tyrrell
Journal:  Epidemiol Infect       Date:  1990-10       Impact factor: 2.451

Review 5.  Medical reviews. Coronaviruses.

Authors:  A S Monto
Journal:  Yale J Biol Med       Date:  1974-12

6.  Brief clinical evaluation of six high-throughput SARS-CoV-2 IgG antibody assays.

Authors:  Niko Kohmer; Sandra Westhaus; Cornelia Rühl; Sandra Ciesek; Holger F Rabenau
Journal:  J Clin Virol       Date:  2020-06-01       Impact factor: 3.168

7.  A Case of Early Re-infection with SARS-CoV-2.

Authors:  Derek Larson; Sterling L Brodniak; Logan J Voegtly; Regina Z Cer; Lindsay A Glang; Francisco J Malagon; Kyle A Long; Ronald Potocki; Darci R Smith; Charlotte Lanteri; Timothy Burgess; Kimberly A Bishop-Lilly
Journal:  Clin Infect Dis       Date:  2020-09-19       Impact factor: 9.079

8.  Definitions for COVID-19 reinfection, relapse and PCR re-positivity.

Authors:  Dafna Yahav; Dana Yelin; Isabella Eckerle; Christiane S Eberhardt; Jianwei Wang; Bin Cao; Laurent Kaiser
Journal:  Clin Microbiol Infect       Date:  2020-12-04       Impact factor: 8.067

9.  Genomic evidence for reinfection with SARS-CoV-2: a case study.

Authors:  Richard L Tillett; Joel R Sevinsky; Paul D Hartley; Heather Kerwin; Natalie Crawford; Andrew Gorzalski; Chris Laverdure; Subhash C Verma; Cyprian C Rossetto; David Jackson; Megan J Farrell; Stephanie Van Hooser; Mark Pandori
Journal:  Lancet Infect Dis       Date:  2020-10-12       Impact factor: 25.071

10.  Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers.

Authors:  Sheila F Lumley; Denise O'Donnell; Nicole E Stoesser; Philippa C Matthews; Alison Howarth; Stephanie B Hatch; Brian D Marsden; Stuart Cox; Tim James; Fiona Warren; Liam J Peck; Thomas G Ritter; Zoe de Toledo; Laura Warren; David Axten; Richard J Cornall; E Yvonne Jones; David I Stuart; Gavin Screaton; Daniel Ebner; Sarah Hoosdally; Meera Chand; Derrick W Crook; Anne-Marie O'Donnell; Christopher P Conlon; Koen B Pouwels; A Sarah Walker; Tim E A Peto; Susan Hopkins; Timothy M Walker; Katie Jeffery; David W Eyre
Journal:  N Engl J Med       Date:  2020-12-23       Impact factor: 91.245
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  2 in total

1.  In response to crisis, is versatility a reward or a necessity.

Authors:  Anton Emmanuel
Journal:  Clin Med (Lond)       Date:  2021-09       Impact factor: 5.410

2.  Avidity of IgG to SARS-CoV-2 RBD as a Prognostic Factor for the Severity of COVID-19 Reinfection.

Authors:  Victor Manuylov; Olga Burgasova; Olga Borisova; Svetlana Smetanina; Daria Vasina; Igor Grigoriev; Alexandra Kudryashova; Maria Semashko; Bogdan Cherepovich; Olga Kharchenko; Denis Kleymenov; Elena Mazunina; Artem Tkachuk; Vladimir Gushchin
Journal:  Viruses       Date:  2022-03-16       Impact factor: 5.048
  2 in total

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