| Literature DB >> 34505522 |
P Sun1, R Li, Y Meng, S Xi, Q Wang, X Yang, X Peng, J Cai.
Abstract
Cancer is a complex, multifactorial disease that modern medicine ultimately aims to overcome. Downstream of tyrosine kinase 2 (DOK2) is a well-known tumor suppressor gene, and a member of the downstream protein DOK family of tyrosine kinases. Through a search of original literature indexed in PubMed and other databases, the present review aims to extricate the mechanisms by which DOK2 acts on cancer, thereby identifying more reliable and effective therapeutic targets to promote enhanced methods of cancer prevention and treatment. The review focuses on the role of DOK2 in multiple tumor types in the lungs, intestines, liver, and breast. Additionally, we discuss the potential mechanisms of action of DOK2 and the downstream consequences via the Ras/MPAK/ERK or PI3K/AKT/mTOR signaling pathways.Entities:
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Year: 2021 PMID： 34505522 PMCID： PMC8820521 DOI： 10.33549/physiolres.934710
Source DB: PubMed Journal: Physiol Res ISSN： 0862-8408 Impact factor: 1.881