| Literature DB >> 3450512 |
T Ishizuka1, K Kajita, K Kamikubo, T Komaki, K Miura, S Nagao, Y Nozawa.
Abstract
We have examined the activities of phospholipid/Ca2+-dependent and cyclic AMP-dependent protein kinases of the parathyroid adenomas and the atrophic glands which were resected from three patients with primary hyperparathyroidism. Phospholipid/Ca2+-dependent protein kinase activity of atrophic parathyroid gland was exclusively present in cytosol fraction (90.7 +/- 12.3%). On the other hand, phospholipid/Ca2+-dependent protein kinase activity of parathyroid adenomas was 66.9 +/- 6.4% in cytosol and 33.1 +/- 6.4% in membrane fraction, suggesting a translocation of the enzyme from the cytosol to the membranes. Cyclic AMP-dependent protein kinase activity appeared to be higher in parathyroid adenoma than in atrophic parathyroid gland in both cytosol and membrane fractions.Entities:
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Year: 1987 PMID: 3450512 DOI: 10.1507/endocrj1954.34.965
Source DB: PubMed Journal: Endocrinol Jpn ISSN: 0013-7219