| Literature DB >> 34504302 |
Camila de Almeida Velozo1, Tailah Bernardo de Almeida1,2, Marcelo Costa Velho Mendes de Azevedo3, Isabela Espasandin1,4, Jorge Francisco da Cunha Pinto3, Sheila López5, Luciana Pizzatti5, Amilcar Tanuri1, Sabrina da Silva Santos6, Marcelo Ribeiro-Alves7, Cynthia Chester Cardoso8.
Abstract
Virologic failure of antiretroviral therapy (ART) may be explained by single nucleotide polymorphisms (SNPs) in drug absorption and metabolism genes. Here, we characterized the associations between polymorphisms in cytochrome P450 enzymes' genes CYP2B6 and CYP3A4/A5, nuclear receptor genes NR1I2/3, and initial ART efficacy among 203 HIV-positive individuals from Rio de Janeiro. Association between SNPs and virologic control was evaluated after 6 and 12 months of follow-up using Cox regression models. The SNP rs2307424 (NR1I3) was associated with increased virologic response after 12 months of treatment, while rs1523127 (NR1I2), rs3003596, and rs2502815 (NR1I3) were associated with decreased response. Increased virologic response after 12 months (adjHR = 1.54; p = 0.02) was also observed among carriers of the NR1I3 haplotype rs2502815G-rs3003596A-rs2307424A versus the reference haplotype G-A-G. Our results suggest that NR1I2 and NR1I3 variants are associated with virologic responses to ART among Brazilians.Entities:
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Year: 2021 PMID： 34504302 DOI： 10.1038/s41397-021-00254-4
Source DB: PubMed Journal: Pharmacogenomics J ISSN： 1470-269X Impact factor: 3.550