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Literature DB >> 34503834

Topical analgesic BENGAY® reduces myocardial infarct size in rodents.

Candida L Goodnough¹, Yun Wu², Eric R Gross³.

Abstract

Entities: Chemical

Keywords: BENGAY; infarct size; ischemia; menthol; methyl salicylate; reperfusion injury; topical analgesic

Mesh：

Substances：
Analgesics
Menthol

Year: 2021 PMID： 34503834 PMCID： PMC8647688 DOI： 10.1016/j.bja.2021.07.029

Source DB: PubMed Journal: Br J Anaesth ISSN： 0007-0912 Impact factor: 9.166

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References

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8 in total

1. Peripheral nociception associated with surgical incision elicits remote nonischemic cardioprotection via neurogenic activation of protein kinase C signaling.

Authors: W Keith Jones; Guo-Chang Fan; Siyun Liao; Jun-Ming Zhang; Yang Wang; Neal L Weintraub; Evangelia G Kranias; Jo El Schultz; John Lorenz; Xiaoping Ren
Journal: Circulation Date: 2009-09-15 Impact factor: 29.690

2. Transient Receptor Potential Ankyrin 1 Activation within the Cardiac Myocyte Limits Ischemia-reperfusion Injury in Rodents.

Authors: Yao Lu; Honit Piplani; Stacy L McAllister; Carl M Hurt; Eric R Gross
Journal: Anesthesiology Date: 2016-12 Impact factor: 7.892

3. Non-opioid analgesic use and concerns for impaired organ protection.

Authors: Y Wu; H M Heymann; E R Gross
Journal: Br J Anaesth Date: 2017-11-26 Impact factor: 9.166

4. Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism.

Authors: Haoxing Xu; Nathaniel T Blair; David E Clapham
Journal: J Neurosci Date: 2005-09-28 Impact factor: 6.167

Topical analgesic BENGAY® reduces myocardial infarct size in rodents.

1. Peripheral nociception associated with surgical incision elicits remote nonischemic cardioprotection via neurogenic activation of protein kinase C signaling.

2. Transient Receptor Potential Ankyrin 1 Activation within the Cardiac Myocyte Limits Ischemia-reperfusion Injury in Rodents.

3. Non-opioid analgesic use and concerns for impaired organ protection.

4. Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism.

5. Nociceptive-induced myocardial remote conditioning is mediated by neuronal gamma protein kinase C.

6. The menthol receptor TRPM8 is the principal detector of environmental cold.

7. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin.

8. IcyHot analgesic topical cream limits cardiac injury in rodents.