Literature DB >> 3450189

Prodrugs as drug delivery systems. 74. Facile hydrolysis of N-(acyloxymethyl)amide derivatives and implications for the design of prodrugs of NH-acidic compounds and of carboxylic acids.

H Bundgaard, N M Nielsen.   

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Year:  1987        PMID： 3450189

Source DB:  PubMed          Journal:  Acta Pharm Suec        ISSN： 0001-6675


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  4 in total

1.  Acyloxymethyl as a drug protecting group: Part 4. The hydrolysis of tertiary amidomethyl ester prodrugs of carboxylic acid agents.

Authors:  J Iley; R Moreira; T Calheiros; E Mendes
Journal:  Pharm Res       Date:  1997-11       Impact factor: 4.200

2.  Acyloxymethyl as a drug protecting group. Part 3. Tertiary O-amidomethyl esters of penicillin G: chemical hydrolysis and anti-bacterial activity.

Authors:  R Moreira; T Calheiros; J Cabrita; E Mendes; M Pimentel; J Iley
Journal:  Pharm Res       Date:  1996-01       Impact factor: 4.200

3.  Growth inhibition, G(1)-arrest, and apoptosis in MCF-7 human breast cancer cells by novel highly lipophilic 5-fluorouracil derivatives.

Authors:  Juan Antonio Marchal; Houria Boulaiz; Inés Suárez; Estrella Saniger; Joaquín Campos; Esmeralda Carrillo; José Prados; Miguel Angel Gallo; Antonio Espinosa; Antonia Aránega
Journal:  Invest New Drugs       Date:  2004-11       Impact factor: 3.850

4.  Prodrugs of peptides. 11. Chemical and enzymatic hydrolysis kinetics of N-acyloxymethyl derivatives of a peptide-like bond.

Authors:  H Bundgaard; G J Rasmussen
Journal:  Pharm Res       Date:  1991-10       Impact factor: 4.200
  4 in total

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