Alberto Raggi1, Lorenzo Monasta2, Ettore Beghi3, Valeria Caso4, Giulio Castelpietra5, Stefania Mondello6, Giorgia Giussani3, Giancarlo Logroscino7, Francesca Giulia Magnani8, Marco Piccininni9, Elisabetta Pupillo3, Stefano Ricci10, Luca Ronfani2, Paola Santalucia11, Davide Sattin8, Silvia Schiavolin8, Claudia Toppo8, Eugenio Traini2,12, Jaimie Steinmetz13, Emma Nichols13, Rui Ma13, Theo Vos13, Valery Feigin14, Matilde Leonardi8. 1. Neurology, Public Health and Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy. alberto.raggi@istituto-besta.it. 2. S.C.R. Epidemiologia Clinica e Ricerca Sui Servizi Sanitari, IRCCS Materno Infantile "Burlo Garofolo", Trieste, Italy. 3. Department of Neurosciences, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. 4. Stroke Unit and Division of Internal and Cardiovascular Medicine, Università di Perugia, Perugia, Italy. 5. Region Friuli Venezia Giulia, Central Health Directorate, Outpatient and Inpatient Care Service, Trieste, Italy. 6. Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. 7. Department of Basic Medical Sciences, Neuroscience, and Sense Organs, Università di Bari Aldo Moro, Bari, Italy. 8. Neurology, Public Health and Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy. 9. Institute of Public Health, Charité-Universitätsmedizin Berlin, Berlin, Germany. 10. Neurology and Stroke Unit, USL Umbria 1, Gubbio and Città di Castello Hospital, Perugia, Italy. 11. Neurology and Stroke Unit, Ospedale San Giuseppe-Multimedica, Milan, Italy. 12. Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands. 13. Institute for Health Metrics and Evaluation, University of Washington, Seattle, USA. 14. National Institute for Stroke and Applied Neurosciences, Auckland University of Technology, Auckland, Australia.
Abstract
BACKGROUND: Neurological conditions are highly prevalent and disabling, in particular in the elderly. The Italian population has witnessed sharp ageing and we can thus expect a rising trend in the incidence, prevalence and disability of these conditions. METHODS: We relied on the Global Burden of Disease 2019 study to extract Italian data on incidence, prevalence and years lived with a disability (YLDs) referred to a broad set of neurological disorders including, brain and nervous system cancers, stroke, encephalitis, meningitis, tetanus, traumatic brain injury, and spinal cord injury. We assessed changes between 1990 and 2019 in counts and age-standardized rates. RESULTS: The most prevalent conditions were tension-type headache, migraine, and dementias, whereas the most disabling were migraine, dementias and traumatic brain injury. YLDs associated with neurological conditions increased by 22.5%, but decreased by 2.3% in age-standardized rates. The overall increase in prevalence and YLDs counts was stronger for non-communicable diseases with onset in old age compared to young to adult-age onset ones. The same trends were in the opposite direction when age-standardized rates were taken into account. CONCLUSIONS: The increase in YLDs associated with neurological conditions is mostly due to population ageing and growth: nevertheless, lived disability and, as a consequence, impact on health systems has increased. Actions are needed to improve outcome and mitigate disability associated with neurological conditions, spanning among diagnosis, treatment, care pathways and workplace interventions.
BACKGROUND: Neurological conditions are highly prevalent and disabling, in particular in the elderly. The Italian population has witnessed sharp ageing and we can thus expect a rising trend in the incidence, prevalence and disability of these conditions. METHODS: We relied on the Global Burden of Disease 2019 study to extract Italian data on incidence, prevalence and years lived with a disability (YLDs) referred to a broad set of neurological disorders including, brain and nervous system cancers, stroke, encephalitis, meningitis, tetanus, traumatic brain injury, and spinal cord injury. We assessed changes between 1990 and 2019 in counts and age-standardized rates. RESULTS: The most prevalent conditions were tension-type headache, migraine, and dementias, whereas the most disabling were migraine, dementias and traumatic brain injury. YLDs associated with neurological conditions increased by 22.5%, but decreased by 2.3% in age-standardized rates. The overall increase in prevalence and YLDs counts was stronger for non-communicable diseases with onset in old age compared to young to adult-age onset ones. The same trends were in the opposite direction when age-standardized rates were taken into account. CONCLUSIONS: The increase in YLDs associated with neurological conditions is mostly due to population ageing and growth: nevertheless, lived disability and, as a consequence, impact on health systems has increased. Actions are needed to improve outcome and mitigate disability associated with neurological conditions, spanning among diagnosis, treatment, care pathways and workplace interventions.
Authors: Paolo Mazzola; Stefania Maria Lorenza Rimoldi; Paolo Rossi; Marianna Noale; Federico Rea; Carla Facchini; Stefania Maggi; Giovanni Corrao; Giorgio Annoni Journal: Gerontologist Date: 2015-11-09
Authors: Joshua A Salomon; Juanita A Haagsma; Adrian Davis; Charline Maertens de Noordhout; Suzanne Polinder; Arie H Havelaar; Alessandro Cassini; Brecht Devleesschauwer; Mirjam Kretzschmar; Niko Speybroeck; Christopher J L Murray; Theo Vos Journal: Lancet Glob Health Date: 2015-11 Impact factor: 26.763
Authors: Robert Belvís; Pablo Irimia; Patricia Pozo-Rosich; Carmen González-Oria; Antonio Cano; Javier Viguera; Belén Sánchez; Francisco Molina; Isabel Beltrán; Agustín Oterino; Elisa Cuadrado; Angel Gómez-Camello; Miguel Alberte-Woodward; Carmen Jurado; Teresa Oms; David Ezpeleta; Javier Díaz de Terán; Noemí Morollón; Germán Latorre; Marta Torres-Ferrús; Alicia Alpuente; Raquel Lamas; Carlos Toledano; Rogelio Leira; Sonia Santos; Margarita Sánchez Del Río Journal: J Headache Pain Date: 2021-07-17 Impact factor: 7.277