Literature DB >> 3449110

Effect of 1 alpha-hydroxyvitamin D3 on osteoporosis induced by immobilization combined with ovariectomy in rats.

H Okumura1, T Yamamuro, R Kasai, T Hayashi, K Tada, Y Nishii.   

Abstract

The effect of low-dose 1 alpha-hydroxyvitamin D3 [1 alpha(OH)D3] on experimental osteoporosis in rats induced by a combination of hemicordotomy and ovariectomy was evaluated. 1 alpha(OH)D3 (0.1 microgram/kg 1 alpha(OH)D3 three times a week) increased the femur score and photo-density. The administration of 1 alpha(OH)D3 also significantly increased the dry weight and ash weight of the bone. Histomorphometry revealed a significant decrease of bone resorption by the administration of 1 alpha(OH)D3. Significant decreases in 45Ca accretion rate and 14C-proline uptake were also observed. Bone formation in the 1 alpha(OH)D3 treated group was thought to decrease following the decrease of bone resorption.

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Year:  1987        PMID： 3449110     DOI： 10.1016/8756-3282(87)90066-4

Source DB:  PubMed          Journal:  Bone        ISSN： 1873-2763            Impact factor:   4.398


  13 in total

1.  Bone loss from the human distal tibia epiphysis during 24 days of unilateral lower limb suspension.

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2.  Ineffectiveness of calcitonin on a local-disuse osteoporosis in the sheep: a histomorphometric study.

Authors:  T Thomas; T M Skerry; L Vico; F Caulin; L E Lanyon; C Alexandre
Journal:  Calcif Tissue Int       Date:  1995-09       Impact factor: 4.333

3.  Effect of ovariectomy and prednisolone on bone mineral content in rats: evaluation by single photon absorptiometry and radiogrammetry.

Authors:  P Geusens; J Dequeker; J Nijs; E Bramm
Journal:  Calcif Tissue Int       Date:  1990-10       Impact factor: 4.333

4.  Prevention and treatment of osteopenia in the ovariectomized rat: effect of combined therapy with estrogens, 1-alpha vitamin D, and prednisolone.

Authors:  P Geusens; J Dequeker; J Nijs; A Verstraeten; E Bramm
Journal:  Calcif Tissue Int       Date:  1991-02       Impact factor: 4.333

5.  Role of vitamin D metabolites in the prevention of the osteopenia induced by ovariectomy in the axial and appendicular skeleton of the rat.

Authors:  R G Erben; B Kohn; H Weiser; F Sinowatz; W A Rambeck
Journal:  Z Ernahrungswiss       Date:  1990-12

6.  Vitamin D metabolites prevent vertebral osteopenia in ovariectomized rats.

Authors:  R G Erben; H Weiser; F Sinowatz; W A Rambeck; H Zucker
Journal:  Calcif Tissue Int       Date:  1992-03       Impact factor: 4.333

7.  Effects of combined and separate intermittent administration of low-dose human parathyroid hormone fragment (1-34) and 17 beta-estradiol on bone histomorphometry in ovariectomized rats with established osteopenia.

Authors:  V Shen; D W Dempster; R W Mellish; R Birchman; W Horbert; R Lindsay
Journal:  Calcif Tissue Int       Date:  1992-03       Impact factor: 4.333

8.  Increase in femoral bone mass by ipriflavone alone and in combination with 1 alpha-hydroxyvitamin D3 in growing rats with skeletal unloading.

Authors:  K Notoya; K Yoshida; R Tsukuda; S Taketomi; M Tsuda
Journal:  Calcif Tissue Int       Date:  1996-02       Impact factor: 4.333

9.  Elongation of the side chain of analogs of 1 alpha,25-dihydroxyvitamin D3 prevents osteopenia in a rat model.

Authors:  M Harada; T Takamura; S Kajita-Kondo; A Kozakai; T Miyahara; H Kozuka; N Ikekawa; S Higuchi; S Otomo
Journal:  Calcif Tissue Int       Date:  1995-03       Impact factor: 4.333

Review 10.  The laboratory rat as an animal model for osteoporosis research.

Authors:  Pavlos P Lelovas; Theodoros T Xanthos; Sofia E Thoma; George P Lyritis; Ismene A Dontas
Journal:  Comp Med       Date:  2008-10       Impact factor: 0.982
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