| Literature DB >> 34489601 |
Jihoon W Lee1, Yapeng Su2,3,4, Priyanka Baloni5, Daniel Chen5, Ana Jimena Pavlovitch-Bedzyk6, Dan Yuan5, Venkata R Duvvuri5, Rachel H Ng5, Jongchan Choi5, Jingyi Xie5, Rongyu Zhang5, Kim Murray5, Sergey Kornilov5, Brett Smith5, Andrew T Magis5, Dave S B Hoon7, Jennifer J Hadlock5, Jason D Goldman8,9,10, Nathan D Price5,11, Raphael Gottardo12,13,14, Mark M Davis6,15,16, Leroy Hood5,9, Philip D Greenberg17,18, James R Heath19,20.
Abstract
A better understanding of the metabolic alterations in immune cells during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may elucidate the wide diversity of clinical symptoms experienced by individuals with coronavirus disease 2019 (COVID-19). Here, we report the metabolic changes associated with the peripheral immune response of 198 individuals with COVID-19 through an integrated analysis of plasma metabolite and protein levels as well as single-cell multiomics analyses from serial blood draws collected during the first week after clinical diagnosis. We document the emergence of rare but metabolically dominant T cell subpopulations and find that increasing disease severity correlates with a bifurcation of monocytes into two metabolically distinct subsets. This integrated analysis reveals a robust interplay between plasma metabolites and cell-type-specific metabolic reprogramming networks that is associated with disease severity and could predict survival.Entities:
Mesh：
Year: 2021 PMID： 34489601 PMCID： PMC9206886 DOI： 10.1038/s41587-021-01020-4
Source DB: PubMed Journal: Nat Biotechnol ISSN： 1087-0156 Impact factor: 68.164