Literature DB >> 34486483

USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3.

Baoshan Cai1, Jian Zhao1, Yuling Zhang1, Yaxing Liu1, Chunhong Ma1, Fan Yi2, Yi Zheng1, Lei Zhang1, Tian Chen3, Huiqing Liu2, Bingyu Liu1, Chengjiang Gao1.   

Abstract

ABBREVIATIONS: 3-MA: 3-methyladenine; AIM2: absent in melanoma 2; ATG5: autophagy related 5; BafA1: bafilomycin A1; CASP1: caspase 1; CHX: cycloheximide; Co-IP: co-immunoprecipitation; CQ: chloroquine; DUBs: deubiquitinases; IL1B/IL-1β: interleukin 1 beta; LAMP1: lysosomal associated membrane protein 1; LPS: lipopolysaccharide; MARCHF7/MARCH7: membrane associated RING-CH-type finger 7; NFKB/NF-κB: nuclear factor kappa B; Nig.: nigericin; NLRC4: NLR family CARD domain containing 4; NLRP3: NLR family pyrin domain containing 3; PECs: peritoneal exudate cells; PMN: polymorphonuclear; PMs: peritoneal macrophages; PYCARD/ASC: PYD and CARD domain containing; TLRs: toll like receptors; TNF/TNF-α: tumor necrosis factor; Ub: ubiquitin; USP5: ubiquitin specific peptidase 5; WT: wild type.

Entities:  

Keywords:  Autophagy-lysosome pathway; MARCHF7; NLRP3 inflammasome; USP5; deubiquitinase

Mesh:

Substances:

Year:  2021        PMID: 34486483      PMCID: PMC9196652          DOI: 10.1080/15548627.2021.1965426

Source DB:  PubMed          Journal:  Autophagy        ISSN: 1554-8627            Impact factor:   13.391


  46 in total

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Authors:  Andrea Stutz; Carl-Christian Kolbe; Rainer Stahl; Gabor L Horvath; Bernardo S Franklin; Olivia van Ray; Rebecca Brinkschulte; Matthias Geyer; Felix Meissner; Eicke Latz
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9.  Autophagy and mitochondrial alterations in human retinal pigment epithelial cells induced by ethanol: implications of 4-hydroxy-nonenal.

Authors:  M Flores-Bellver; L Bonet-Ponce; J M Barcia; J M Garcia-Verdugo; N Martinez-Gil; S Saez-Atienzar; J Sancho-Pelluz; J Jordan; M F Galindo; F J Romero
Journal:  Cell Death Dis       Date:  2014-07-17       Impact factor: 8.469

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7.  Cannabinoid receptor-2 attenuates neuroinflammation by promoting autophagy-mediated degradation of the NLRP3 inflammasome post spinal cord injury.

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  7 in total

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