PURPOSE: The aim of this study was to report a case of human keratoconjunctivitis caused by both Newcastle disease virus (NDV) and human adenovirus. METHODS: A 32-year-old-man presented with an acute unilateral keratoconjunctivitis that resolved with corneal scarring. On presentation, his conjunctival swab was collected for metagenomic sequencing. RESULTS: The highest number of pathogen sequencing reads in the conjunctival sample mapped to the NDV. The second highest number of reads mapped to human adenovirus. Confirmation testing with directed reverse-transcription polymerase chain reaction also identified NDV in the specimen. CONCLUSIONS: Newcastle conjunctivitis has not been reported for more than 40 years. Mixed infections, including zoonotic pathogens, may be more common than realized.
PURPOSE: The aim of this study was to report a case of human keratoconjunctivitis caused by both Newcastle disease virus (NDV) and human adenovirus. METHODS: A 32-year-old-man presented with an acute unilateral keratoconjunctivitis that resolved with corneal scarring. On presentation, his conjunctival swab was collected for metagenomic sequencing. RESULTS: The highest number of pathogen sequencing reads in the conjunctival sample mapped to the NDV. The second highest number of reads mapped to human adenovirus. Confirmation testing with directed reverse-transcription polymerase chain reaction also identified NDV in the specimen. CONCLUSIONS: Newcastle conjunctivitis has not been reported for more than 40 years. Mixed infections, including zoonotic pathogens, may be more common than realized.
Authors: David A Sutton; David P Allen; Chad M Fuller; Jo Mayers; Benjamin C Mollett; Brandon Z Londt; Scott M Reid; Karen L Mansfield; Ian H Brown Journal: J Virol Methods Date: 2018-12-21 Impact factor: 2.014
Authors: Thuy Doan; Michael R Wilson; Emily D Crawford; Eric D Chow; Lillian M Khan; Kristeene A Knopp; Brian D O'Donovan; Dongxiang Xia; Jill K Hacker; Jay M Stewart; John A Gonzales; Nisha R Acharya; Joseph L DeRisi Journal: Genome Med Date: 2016-08-25 Impact factor: 11.117
Authors: Luciano M Thomazelli; Juliana A Sinhorini; Danielle B L Oliveira; Terezinha Knöbl; Tatiana C M Bosqueiro; Elder Sano; Gladyston C V Costa; Cairo Monteiro; Erick G Dorlass; Nathalia Utecht; Guilherme P Scagion; Carla Meneguin; Laura M N Silva; Maria Vitória S Moraes; Larissa M Bueno; Dilmara Reischak; Adriano O T Carrasco; Clarice W Arns; Helena L Ferreira; Edison L Durigon Journal: Viruses Date: 2021-12-06 Impact factor: 5.048