Literature DB >> 34480863

Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models.

Yasaman Aghazadeh1, Frankie Poon2, Farida Sarangi3, Frances T M Wong4, Safwat T Khan5, Xuetao Sun6, Rupal Hatkar6, Brian J Cox7, Sara S Nunes8, M Cristina Nostro9.   

Abstract

Islet transplantation is a promising treatment for type 1 diabetes (T1D), yet the low donor pool, poor islet engraftment, and life-long immunosuppression prevent it from becoming the standard of care. Human embryonic stem cell (hESC)-derived pancreatic cells could eliminate donor shortages, but interventions to improve graft survival are needed. Here, we enhanced subcutaneous engraftment by employing a unique vascularization strategy based on ready-made microvessels (MVs) isolated from the adipose tissue. This resulted in improved cell survival and effective glucose response of both human islets and hESC-derived pancreatic cells, which ameliorated preexisting diabetes in three mouse models of T1D. Crown
Copyright © 2021. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  beta cells; embryonic stem cells; endothelial cells; islet transplantation; microvessels; pancreatic progenitors; regenerative medicine; subcutaneous; type 1 diabetes; vascularization

Mesh：

Year:  2021        PMID： 34480863     DOI： 10.1016/j.stem.2021.08.001

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  9 in total

Review 1.  State of the field: cellular and exosomal therapeutic approaches in vascular regeneration.

Authors:  Evan Paul Tracy; Virginia Stielberg; Gabrielle Rowe; Daniel Benson; Sara S Nunes; James B Hoying; Walter Lee Murfee; Amanda Jo LeBlanc
Journal:  Am J Physiol Heart Circ Physiol       Date:  2022-02-18       Impact factor: 4.733

2.  Engineering Functional Vascularized Beige Adipose Tissue from Microvascular Fragments of Models of Healthy and Type II Diabetes Conditions.

Authors:  Francisca M Acosta; Katerina Stojkova; Jingruo Zhang; Eric Ivan Garcia Huitron; Jean X Jiang; Christopher R Rathbone; Eric M Brey
Journal:  J Tissue Eng       Date:  2022-06-24       Impact factor: 7.940

Review 3.  Pancreatic Organoids for Regenerative Medicine and Cancer Research.

Authors:  Joan Casamitjana; Elisa Espinet; Meritxell Rovira
Journal:  Front Cell Dev Biol       Date:  2022-05-03

Review 4.  Methods for vascularization and perfusion of tissue organoids.

Authors:  Hannah A Strobel; Sarah M Moss; James B Hoying
Journal:  Mamm Genome       Date:  2022-03-25       Impact factor: 3.224

5.  Pancreatic islets in bed with microvasculature-companions for life.

Authors:  Corinne A Hoesli; Timothy J Kieffer
Journal:  Cell Rep Med       Date:  2021-11-16

Review 6.  Stem Cell Transplantation in the Treatment of Type 1 Diabetes Mellitus: From Insulin Replacement to Beta-Cell Replacement.

Authors:  Xin-Xing Wan; Dan-Yi Zhang; Md Asaduzzaman Khan; Sheng-Yuan Zheng; Xi-Min Hu; Qi Zhang; Rong-Hua Yang; Kun Xiong
Journal:  Front Endocrinol (Lausanne)       Date:  2022-03-18       Impact factor: 5.555

7.  A Biofabrication Strategy for a Custom-Shaped, Non-Synthetic Bone Graft Precursor with a Prevascularized Tissue Shell.

Authors:  Sarah M Moss; Monica Ortiz-Hernandez; Dmitry Levin; Chris A Richburg; Thomas Gerton; Madison Cook; Jeffrey J Houlton; Zain H Rizvi; Paul C Goodwin; Michael Golway; Beth Ripley; James B Hoying
Journal:  Front Bioeng Biotechnol       Date:  2022-03-09

8.  GP2-enriched pancreatic progenitors give rise to functional beta cells in vivo and eliminate the risk of teratoma formation.

Authors:  Yasaman Aghazadeh; Farida Sarangi; Frankie Poon; Blessing Nkennor; Emily C McGaugh; Sara S Nunes; M Cristina Nostro
Journal:  Stem Cell Reports       Date:  2022-03-31       Impact factor: 7.294

Review 9.  Angiorganoid: vitalizing the organoid with blood vessels.

Authors:  Xiaojing Ma; Hongfei Li; Shuntian Zhu; Zixuan Hong; Weijing Kong; Qihang Yuan; Runrong Wu; Zihang Pan; Jing Zhang; Yahong Chen; Xi Wang; Kai Wang
Journal:  Vasc Biol       Date:  2022-08-01
  9 in total

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