Mengqi Liu1, Fajin Lv1, Yineng Zheng1, Kaihu Xiao2,3. 1. Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 2. Department of Cardiology, Chongqing University Three Gorges Hospital, Chongqing, China. 3. Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Abstract
BACKGROUND: This study investigated patients' long-term radiological and physiological outcomes with coronavirus disease 2019 (COVID-19). METHODS: A total of 52 patients (26 men and 26 women, 32 with moderate COVID-19 and 20 with severe COVID-19, with a median age of 50.5 years) who had COVID-19 participated in this study. Follow-up thin-section chest computed tomography (CT) scans were performed at 1, 3, and 6 months after discharge. Cardiopulmonary exercise testing was performed on 37 patients 6 months after discharge. The clinical data and the chest CT findings were recorded and analyzed. RESULTS: The predominant chest CT patterns of abnormalities observed at 6 months after discharge were parenchymal band, interlobular septal thickening, and traction bronchiectasis. The cumulative percentage of the complete radiological resolution was 17%, 42%, 67%, and 75% at discharge and 1, 3, and 6 months after discharge, respectively. A subgroup analysis revealed that 88% of patients with moderate type and 55% of patients with severe type COVID-19 achieved complete radiological resolution at 6 months after discharge, and the difference between the 2 groups was significant (P<0.001). The following risk factors were found to be associated with an incomplete radiological resolution at 6 months after discharge: an age >50 years old, the severe type of COVID-19, a hospital stay >18 days, mechanical ventilation, steroid therapy, immunoglobin therapy, an opacity score at discharge >4, and a volume of opacity at discharge >235 mL. CONCLUSIONS: Chest CT lesions were absorbed without any sequelae in most patients with COVID-19; however, fibrotic-like changes and cardiopulmonary insufficiency were still present in a considerable proportion of COVID-19 survivors at 6 months after discharge, especially in patients with severe type COVID-19. 2021 Quantitative Imaging in Medicine and Surgery. All rights reserved.
BACKGROUND: This study investigated patients' long-term radiological and physiological outcomes with coronavirus disease 2019 (COVID-19). METHODS: A total of 52 patients (26 men and 26 women, 32 with moderate COVID-19 and 20 with severe COVID-19, with a median age of 50.5 years) who had COVID-19 participated in this study. Follow-up thin-section chest computed tomography (CT) scans were performed at 1, 3, and 6 months after discharge. Cardiopulmonary exercise testing was performed on 37 patients 6 months after discharge. The clinical data and the chest CT findings were recorded and analyzed. RESULTS: The predominant chest CT patterns of abnormalities observed at 6 months after discharge were parenchymal band, interlobular septal thickening, and traction bronchiectasis. The cumulative percentage of the complete radiological resolution was 17%, 42%, 67%, and 75% at discharge and 1, 3, and 6 months after discharge, respectively. A subgroup analysis revealed that 88% of patients with moderate type and 55% of patients with severe type COVID-19 achieved complete radiological resolution at 6 months after discharge, and the difference between the 2 groups was significant (P<0.001). The following risk factors were found to be associated with an incomplete radiological resolution at 6 months after discharge: an age >50 years old, the severe type of COVID-19, a hospital stay >18 days, mechanical ventilation, steroid therapy, immunoglobin therapy, an opacity score at discharge >4, and a volume of opacity at discharge >235 mL. CONCLUSIONS: Chest CT lesions were absorbed without any sequelae in most patients with COVID-19; however, fibrotic-like changes and cardiopulmonary insufficiency were still present in a considerable proportion of COVID-19 survivors at 6 months after discharge, especially in patients with severe type COVID-19. 2021 Quantitative Imaging in Medicine and Surgery. All rights reserved.
Authors: Gregory E Antonio; K T Wong; David S C Hui; Alan Wu; Nelson Lee; Edmund H Y Yuen; C B Leung; T H Rainer; Peter Cameron; Sydney S C Chung; Joseph J Y Sung; Anil T Ahuja Journal: Radiology Date: 2003-06-12 Impact factor: 11.105
Authors: Christopher C Huntley; Ketan Patel; Shahnoor-E-Salam Bil Bushra; Farah Mobeen; Michael N Armitage; Anita Pye; Chloe B Knight; Alyaa Mostafa; Marie Kershaw; Aishah Z Mughal; Emily McKemey; Alice M Turner; P Sherwood Burge; Gareth I Walters Journal: ERJ Open Res Date: 2022-05-30