Teledermatology Service During the COVID-19 Pandemic in China: A Mobile Application-Based Retrospective Study.

PURPOSE: During the COVID-19 pandemic, teledermatology service was increased rapidly. The purpose of our study was to analyze the characteristics of patients and common skin diseases via teledermatology during the COVID-19 pandemic in mainland China. PATIENTS AND METHODS: During weekends between January 21 and April 4, 2020, the data of patients who used teledermatology service via a mobile application were collected, including gender, age, and diagnosis.
RESULTS: A total of 698 patients (315 men and 383 women), with a mean age of 26 years, used this service. The top ten common diseases in order of proportion were eczema (22%), acne (9%), atopic dermatitis (9%), urticaria (5%), contact dermatitis (5%), herpes zoster (3%), warts (3%), folliculitis (3%), prurigo (3%), and androgenetic alopecia (2%). When classified according to age groups, atopic dermatitis was the most common condition for patients in the first decade, acne was more prevalent in the second and third decades, and eczema was the most prevalent condition for all other age groups.
CONCLUSION: The ten common diseases accounted for the majority of the evaluated cases and varied by age group, allowing individualizing teledermatology services.

Introduction

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in December 2019 in Wuhan, Hubei province, China.1 This virus spread rapidly across the globe. The coronavirus disease 2019 (COVID-19) pandemic has challenged healthcare systems, prompting them to change admission protocols and standardize preventive approaches, including social distancing, hand sanitizing, masks, telemedicine and vaccinations.2–8 Although healthcare systems discouraged face-to-face consultations, the demand for dermatological consultations doubled, decreasing patient compliance motivated by misinformation, COVID-19 phobia, and cabin-fever syndrome.8

As a result, the COVID-19 pandemic stimulated the development and implementation of telemedicine services. Telemedicine services are available in 88.5% of counties, cities, and districts of China.9 Some telemedicine applications developed by hospitals and companies are certified by the National Health Commission of the People’s Republic of China, and consultation fees are covered by health insurance in some cities and commercial medical insurance.

The teledermatology service requires patients to provide personal information such as gender, age, medical history, and photographs of skin lesions. Subsequently, patients can have online consultations with registered physicians. There are three types of teledermatology services: synchronous, asynchronous, and hybrid. Asynchronous teledermatology uses the store-and-forward technique, and patient information, including photographs, and medical history, are sent online to a physician, who reviews the information and responds minutes or days later. Synchronous (real-time) teledermatology is conducted via video conference. Hybrid teledermatology combines these two technologies. Asynchronous teledermatology is the most widely used; however, there is no direct communication between physicians and patients. Synchronous teledermatology allows physicians to analyze medical records and perform teledermatologic examinations, improving communication. Hybrid teledermatology is less commonly used because it requires a lot of bandwidth and storage space.10

Some studies evaluated the demographic and clinical characteristics of patients using teledermatology service in different countries during the COVID-19 pandemic.11–16 Several studies were conducted using synchronous teledermatology service in different countries,11,12 but not in China. This study reports the experience of an attending physician providing synchronous teledermatology service via the largest telemedicine application in China.

Materials and Methods

The study was approved by the Ethics Committee of Peking University People’s Hospital, and patient consent to review medical records was waived because all patient data were de-identified and securely stored to protect patient confidentiality. The study was conducted in compliance with the Declaration of Helsinki. Haodaifu platform is one of the largest telemedicine providers in China, with approximately 240,000 physicians, and assisted more than 68 million patients until December 2020. It has synchronous, asynchronous, and hybrid teledermatology services. The author (Dr. Mu) was mainly responsible for the synchronous teledermatology service of the entire platform at 6–10pm every weekend, and there were other physicians responsible for other times. Patients can choose one physician for consultation according to their own schedule. Patients provide personal data, including gender, age, medical history, and photographs of skin lesions via a mobile application and can choose video or phone consultation. The physicians log into the Haodaifu website to check the information and communicate with patients via the smartphone application. Family members, babysitters, or caregivers are responsible for the consultations of children, adolescents, the elderly, and the patients with cognitive or mobility dysfunction. A diagnosis is made based on the information provided during the consultation, and preliminary treatment advice is given. For severe and undetermined conditions, in-person visits to a hospital or clinic are recommended.

Dr. Mu (male) was in charge of the consultation, and two dermatologists independently reviewed the diagnoses (Dr. Liu and Dr. Li). Demographic data, including age, gender, and diagnosis, were retrieved from the Haodaifu website from January 21 to April 4, 2020, and transferred to an Excel spreadsheet (Microsoft Excel for Mac 16.50). Eczema is defined as non-atopic eczema, including ear eczema, hand eczema, xerotic eczema, nummular eczema, diaper dermatitis, and pruritic dermatitis in the elderly.17

Diagnostic information was analyzed and stratified according to gender and age. Statistical analysis was performed using the chi-square test, and p-values of less than 0.05 were considered statistically significant. The data were analyzed using STATA software version 15.1 (Stata Corp, TX) and plotted using Prism version 9 (San Diego, CA).

Results

Demographic Characteristics

A total of 698 patients (315 men and 383 women) made use of this service, of which 55% of the participants were females. The mean age of the patients was 26 years, with the youngest patient being 24 days old and the oldest patient being 93 years old. The service was mostly used by patients in their third decade of life (25%), followed by patients in the fourth (23%) and the fifth decades of life (23%) (Figure 1). The use of teledermatology decreased as the age groups increased. In addition, none of our patients were infected with SARS-COV-2.

Figure 1

Gender composition of the different age groups.

Disease Characteristics

The most common skin diseases were eczema (22%), acne (9%), atopic dermatitis (9%), urticaria (5%), contact dermatitis (5%), herpes zoster (3%), warts (3%), folliculitis (3%), prurigo (3%), and androgenetic alopecia (2%). These ten diseases accounted for 65% of the evaluated cases, and eczema, acne and atopic dermatitis accounted for 40% of all diagnoses (Table 1).

Table 1

Proportion of Skin Diseases in Patients Using Teledermatology Services

Diseases	Total (n, %)
Eczema	153 (22)
Acne	62 (9)
Atopic dermatitis	61 (9)
Urticaria	36 (5)
Contact dermatitis	34 (5)
Herpes zoster	23 (3)
Warts	23 (3)
Folliculitis	21 (3)
Prurigo	21 (3)
Androgenetic alopecia	17 (2)
Tinea pedis	11 (2)
Seborrheic dermatitis	10 (1)
Epidermal cyst	10 (1)
Psoriasis	9 (1)
Scar/keloid	8 (1)
Herpes simplex	7 (1)
Other diseases	151 (22)
Undetermined diagnosis	41 (6)

Gender Differences

The total proportion of these ten common diseases was higher in female patients than that in male patients (68% versus 61%), mainly because of the gender difference in acne (12% versus 5%) (Table 2).

Table 2

Proportion of Top Ten Skin Diseases by Gender

Diseases	Male (n, %)	Female (n, %)	P value
Eczema	67 (21)	86 (22)	0.707
Acne	16 (5)	46 (12)	0.001
Atopic dermatitis	28 (9)	33 (9)	0.899
Urticaria	11 (3)	25 (7)	0.071
Contact dermatitis	14 (4)	20 (5)	0.635
Herpes zoster	11 (3)	12 (3)	0.792
Warts	13 (4)	10 (3)	0.264
Folliculitis	9 (3)	12 (3)	0.832
Prurigo	12 (4)	9 (2)	0.261
Androgenetic alopecia	10 (3)	7 (2)	0.251
Total	191 (61)	260 (68)	0.046

Age Differences

The two most common diseases according to the age group are summarized in Table 3. The most common disease in the first decade of life was atopic dermatitis (32%), acne in the second and third decades (20% and 21%), and eczema in the rest of the age groups (19%, 30%, 28%, and 36%, in the fourth, fifth, sixth and seventh age groups respectively). The second most common disease in each age group was eczema in the first to the third decades, acne in the fourth decade, urticaria in the fifth decade, and heres zoster in the sixth and seventh decades.

Table 3

Proportion of the Two Most Common Skin Diseases Between the Ages of 0 and 69

Age (Years)	Diseases (n, %)		Total (n, %)
0–9	Atopic dermatitis (52, 32)	Eczema (27, 17)	79 (49)
10–19	Acne (14, 20)	Eczema (9, 13)	23 (33)
20–29	Acne (36, 21)	Eczema (30, 17)	66 (38)
30–39	Eczema (31, 19)	Acne (12, 8)	43 (27)
40–49	Eczema (16, 29)	Urticaria (4, 7)	20 (36)
50–59	Eczema (13, 28)	Herpes zoster (3, 7)	16 (35)
60–69	Eczema (9, 36)	Herpes zoster (5, 20)	14 (56)

Discussion

The use of teledermatology service increased significantly during the COVID-19 pandemic. A study found that 72.8% of a cohort could use teledermatology to reduce the risk of COVID-19.18 Other studies reported that patients and physicians were interested in using dermatology service via telemedicine.19,20

Teledermatology is an important part of telemedicine in China, and many interactive websites and mobile applications allow access to these services.21 A survey showed that 18.0% of physicians offering telemedicine service on the Haodaifu platform in 2017 were dermatologists.22 The cost of synchronous teledermatology service is affordable. Taking the Haodaifu application as an example, the consultation fee for new users is one CNY (approximately 0.15 USD), while for regular users it is 29 CNY (approximately 4.5 USD).

Our results indicate that patients aged 20 to 39 years were more likely to utilize teledermatology service, possibly because of the higher use of smartphones. The mean age of patients using these services was lower than that found in previous studies.12–15 Women were more likely to use these services than men, consistent with the literature.12–14 Patients younger than 10 years were the second largest age group, the proportion in the general population according to the 2019 population data (23% versus 11%), which may be because their parents or guardians were usually young (aged 20–39 years). The use of teledermatology was lower in patients older than 60 years, and the proportion of elderly patients using the service was lower than that of the elderly people in the population according to the 2019 population data (4% vs 18%), underscoring the need to develop telemedicine applications that are more user-friendly for this population.

The following skin diseases were previously diagnosed via teledermatology: acne, dermatitis, neoplasms, skin infection, papulosquamous disorders, fungal infection/arthropod bite, and viral diseases in the United States;12 psoriasis, atopic dermatitis, hidradenitis suppurativa, and acne in Italy;13 nevus, acne, eczema, seborrheic dermatitis, actinic keratosis, and basal cell carcinoma in Spain;14 infectious dermatoses, fungal and ectoparasitic infections, papulosquamous disorders, eczema, and dyschromia in India.15 Moreover, an internet-based survey showed that the most common dermatological diseases during the COVID-19 pandemic in China were psoriasis (24.3%), eczema (19.7%), dermatitis (12.8%), vitiligo (11.4%), acne (5.3%), urticaria (2.5%), folliculitis (2.0%), seborrheic dermatitis (1.7%), prurigo (0.85%), and tinea pedis (0.76%).16 These data showed that acne, eczema, and dermatitis were common in almost all studies, including our study. However, the reported incidence of specific skin conditions via telemedicine varied between different countries. This have been investigated and may be related to factors such as race and geography.

Our results agree with a hospital-based study conducted in Japan, whereby the most common skin diseases were eczema, tinea pedis, urticaria/angioedema, tinea unguium, viral warts, psoriasis, acne, as well as atopic, contact, and seborrheic dermatitis.23 The prevalences of common skin diseases in China were androgenetic alopecia (21.3% in men and 6.0% in women), atopic dermatitis (12.94% in children aged 1 to 7 years), acne (8.10%), herpes zoster (annual incidence of 1.9/1000, and lifetime prevalence of 3.46% in people aged 50 years and older), psoriasis (0.47%), and vitiligo (0.56%).24–30 Furthermore, the most common skin diseases in hospitals in China were eczema (19.0–21.8%) and adult atopic dermatitis (4.65%),31–33 in line with our results. In addition, the patients in our cohort lived in almost all provincial-level administrative regions (data not shown), and the findings may provide a good reflection on the prevalence of skin diseases in China during the COVID-19 pandemic.

There were age differences in the prevalence of skin diseases. Eczema was predominant in our cohort, especially in the age group 30–69 years, in line with a previous study.23 Atopic dermatitis was the most common skin disease in pediatric patients in our cohort, and prevalence was higher than that in Japanese children younger than 10 years and Chinese children aged 1–7 years.23,26 Acne ranked first in the age group 10–29 years in our sample and second in Japanese patients aged 16 to 25 years.23 Herpes zoster ranked second in the age group 50–69 years in our population and fourth in Japanese patients aged 81–85 years.23 The higher proportion of herpes zoster in this age group may be associated with the presence of other concomitant symptoms, such as neuralgia, stimulating the use of teledermatology service.

Most skin diseases are relatively easy to diagnose based on medical history and clinical examination, facilitating the clinical application of teledermatology service. A previous study showed that asynchronous teledermatology and synchronous teledermatology was preferred in treating acne and complex dermatological conditions, respectively.12 According to our experience, synchronous telemedicine is an effective communication tool to dermatologists, although dialects may limit patient-physician communication. Furthermore, the poor quality of mobile video limits the analysis of skin lesions. Thus, the patients should be asked to provide good quality photos prior to the video or call to overcome the poor internet quality. In addition, other applications such as WhatsApp have been used in teledermatology. WhatsApp has a large number of users and can deliver synchronous or asynchronous service. However, the limitations of this technology include medical, legal, and ethical issues, privacy, fees, and methods of payment for telemedicine service.34,35

Limitations

This study has limitations. First, although the patients in our cohort presented different skin diseases and came from different regions of China, the data were obtained by one dermatologist using one telemedicine application. Second, age-standardization was not performed, and the results were not compared with face-to-face consultations. Third, the accuracy of diagnosis was not confirmed clinically. In this respect, the diagnostic accuracy of a teledermatology service was less than 90% and lower than that of in-person services.36 Fourth, the sample size was small. Therefore, our findings may not fully reflect the use of teledermatology service by the general population.

Conclusion

During the COVID-19 pandemic, synchronous teledermatology service was used by many young people. The ten common skin diseases in this study accounted for the majority of all diagnoses, especially eczema, acne and atopic dermatitis. Different age groups have their own common skin diseases, and understanding this helps to provide individualized services. Furthermore, patients should provide high-resolution photographs before video conferences or calls to overcome the poor internet quality. With the increase in mobile phone use and network accessibility, the provision and uptake of teledermatology services are expected to increase in the next decades.