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Literature DB >> 3447153

Proteolysis Data Bank: specificity of alpha-chymotrypsin from computation of protein cleavages.

Abstract

The specificity of alpha-chymotrypsin was determined by computation of data retrieved from the Proteolysis Data Bank. The coefficients Kn enable the calculation of the relative influence of the neighbouring amino acid residues in subsites P3--P'3 on the probability of cleavage of polypeptide substrates. The extent of the fixation sites of chymotrypsin and pepsin are compared. The results of the study indicate that predictions of cleavage by proteolytic enzymes can be made from the sequence of polypeptide substrates, provided that a sufficient pool of experimental data has been collected.

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Year: 1987 PMID： 3447153

Source DB: PubMed Journal: Protein Seq Data Anal ISSN： 0931-9506

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Cited

8 in total

1. Isolation and structural characterization of a molecular variant of dog pancreatic secretory trypsin inhibitor.

Authors: J M Conlon; C B Kim; D F Magee
Journal: Int J Pancreatol Date: 1991-01

2. Glycoprotein Enrichment Analytical Techniques: Advantages and Disadvantages.

Authors: R Zhu; L Zacharias; K M Wooding; W Peng; Y Mechref
Journal: Methods Enzymol Date: 2017-01-16 Impact factor: 1.600

3. Comprehensive analysis of protein digestion using six trypsins reveals the origin of trypsin as a significant source of variability in proteomics.

Authors: Scott J Walmsley; Paul A Rudnick; Yuxue Liang; Qian Dong; Stephen E Stein; Alexey I Nesvizhskii
Journal: J Proteome Res Date: 2013-11-14 Impact factor: 4.466

8. Phosphorylation of conserved serine residues does not regulate the ability of mosxe protein kinase to induce oocyte maturation or function as cytostatic factor.

Authors: R S Freeman; A N Meyer; J Li; D J Donoghue
Journal: J Cell Biol Date: 1992-02 Impact factor: 10.539

8 in total

Proteolysis Data Bank: specificity of alpha-chymotrypsin from computation of protein cleavages.

1. Isolation and structural characterization of a molecular variant of dog pancreatic secretory trypsin inhibitor.

2. Glycoprotein Enrichment Analytical Techniques: Advantages and Disadvantages.

3. Comprehensive analysis of protein digestion using six trypsins reveals the origin of trypsin as a significant source of variability in proteomics.

4. Cryptic proteolytic activity of dihydrolipoamide dehydrogenase.

5. Structural determinants of autoproteolysis of the Haemophilus influenzae Hap autotransporter.

6. Easy Bioinformatics Analysis (EBiAn): a package for manipulating and analysis of short biological sequences.

7. Development of a keratinase activity assay using recombinant chicken feather keratin substrates.

8. Phosphorylation of conserved serine residues does not regulate the ability of mosxe protein kinase to induce oocyte maturation or function as cytostatic factor.