Literature DB >> 34462187

Rapid Proliferation Compensates for Defective Filamentation in Candida albicans Pathogenesis.

David Kadosh1.   

Abstract

A recent study (Dunker et al.) has shown that a Candida albicans mutant, defective for filamentation, is fully virulent due to rapid cellular proliferation in host tissues. These findings challenge the current paradigm in C. albicans pathogenesis and suggest that defects in one virulence property can be compensated for by enhancements in another.
Copyright © 2021 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Candida albicans; cellular proliferation; filaments; metabolic adaptation; morphology; pathogenesis; yeast

Mesh：

Year:  2021        PMID： 34462187      PMCID： PMC8815434          DOI： 10.1016/j.tim.2021.08.006

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   18.230


  12 in total

Review 1.  Coevolution of morphology and virulence in Candida species.

Authors:  Delma S Thompson; Patricia L Carlisle; David Kadosh
Journal:  Eukaryot Cell       Date:  2011-07-15

2.  Nonfilamentous C. albicans mutants are avirulent.

Authors:  H J Lo; J R Köhler; B DiDomenico; D Loebenberg; A Cacciapuoti; G R Fink
Journal:  Cell       Date:  1997-09-05       Impact factor: 41.582

3.  Nosocomial bloodstream infections in United States hospitals: a three-year analysis.

Authors:  M B Edmond; S E Wallace; D K McClish; M A Pfaller; R N Jones; R P Wenzel
Journal:  Clin Infect Dis       Date:  1999-08       Impact factor: 9.079

4.  Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection.

Authors:  Stephen P Saville; Anna L Lazzell; Carlos Monteagudo; Jose L Lopez-Ribot
Journal:  Eukaryot Cell       Date:  2003-10

5.  Hgc1, a novel hypha-specific G1 cyclin-related protein regulates Candida albicans hyphal morphogenesis.

Authors:  Xinde Zheng; Yanming Wang; Yue Wang
Journal:  EMBO J       Date:  2004-04-08       Impact factor: 11.598

6.  Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study.

Authors:  Hilmar Wisplinghoff; Tammy Bischoff; Sandra M Tallent; Harald Seifert; Richard P Wenzel; Michael B Edmond
Journal:  Clin Infect Dis       Date:  2004-07-15       Impact factor: 9.079

7.  The Candida albicans-specific gene EED1 encodes a key regulator of hyphal extension.

Authors:  Ronny Martin; Gary P Moran; Ilse D Jacobsen; Antje Heyken; Jenny Domey; Derek J Sullivan; Oliver Kurzai; Bernhard Hube
Journal:  PLoS One       Date:  2011-04-07       Impact factor: 3.240

8.  Global analysis of fungal morphology exposes mechanisms of host cell escape.

Authors:  Teresa R O'Meara; Amanda O Veri; Troy Ketela; Bo Jiang; Terry Roemer; Leah E Cowen
Journal:  Nat Commun       Date:  2015-03-31       Impact factor: 14.919

9.  Filamentation Is Associated with Reduced Pathogenicity of Multiple Non-albicans Candida Species.

Authors:  Mohua Banerjee; Anna L Lazzell; Jesus A Romo; Jose L Lopez-Ribot; David Kadosh
Journal:  mSphere       Date:  2019-10-16       Impact factor: 4.389

10.  Rapid proliferation due to better metabolic adaptation results in full virulence of a filament-deficient Candida albicans strain.

Authors:  Christine Dunker; Melanie Polke; Bianca Schulze-Richter; Katja Schubert; Sven Rudolphi; A Elisabeth Gressler; Tony Pawlik; Juan P Prada Salcedo; M Joanna Niemiec; Silvia Slesiona-Künzel; Marc Swidergall; Ronny Martin; Thomas Dandekar; Ilse D Jacobsen
Journal:  Nat Commun       Date:  2021-06-23       Impact factor: 14.919
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