Literature DB >> 34459989

Determining the structure and binding mechanism of oxytocin-Cu2+ complex using paramagnetic relaxation enhancement NMR analysis.

Israel Alshanski1, Deborah E Shalev2,3, Shlomo Yitzchaik4, Mattan Hurevich5.   

Abstract

Oxytocin is a neuropeptide that binds copper ions in nature. The structure of oxytocin in interaction with Cu2+ was determined here by NMR, showing which atoms of the peptide are involved in binding. Paramagnetic relaxation enhancement NMR analyses indicated a binding mechanism where the amino terminus was required for binding and subsequently Tyr2, Ile3 and Gln4 bound in that order. The aromatic ring of Tyr2 formed a π-cation interaction with Cu2+. Oxytocin copper complex structure revealed by paramagnetic relaxation enhancement NMR analyses.
© 2021. Society for Biological Inorganic Chemistry (SBIC).

Entities:  

Keywords:  Copper complex; Nuclear magnetic resonance; Oxytocin; Paramagnetic resonance enhancement; Peptide

Mesh：

Substances：

Year:  2021        PMID： 34459989     DOI： 10.1007/s00775-021-01897-1

Source DB:  PubMed          Journal:  J Biol Inorg Chem        ISSN： 0949-8257            Impact factor:   3.358


  28 in total

1.  Evoked axonal oxytocin release in the central amygdala attenuates fear response.

Authors:  H Sophie Knobloch; Alexandre Charlet; Lena C Hoffmann; Marina Eliava; Sergey Khrulev; Ali H Cetin; Pavel Osten; Martin K Schwarz; Peter H Seeburg; Ron Stoop; Valery Grinevich
Journal:  Neuron       Date:  2012-02-09       Impact factor: 17.173

Review 2.  The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior.

Authors:  Thomas R Insel
Journal:  Neuron       Date:  2010-03-25       Impact factor: 17.173

3.  Oxytocin-receptor binding: why divalent metals are essential.

Authors:  Dengfeng Liu; Alexandra B Seuthe; Oli T Ehrler; Xiaohua Zhang; Thomas Wyttenbach; Jeffrey F Hsu; Michael T Bowers
Journal:  J Am Chem Soc       Date:  2005-02-23       Impact factor: 15.419

4.  Direct Assembly and Metal-Ion Binding Properties of Oxytocin Monolayer on Gold Surfaces.

Authors:  Evgeniy Mervinetsky; Israel Alshanski; Jörg Buchwald; Arezoo Dianat; Ivor Lončarić; Predrag Lazić; Željko Crljen; Rafael Gutierrez; Gianaurelio Cuniberti; Mattan Hurevich; Shlomo Yitzchaik
Journal:  Langmuir       Date:  2019-08-08       Impact factor: 3.882

Review 5.  Coordination chemistry of copper proteins: how nature handles a toxic cargo for essential function.

Authors:  Jeffrey T Rubino; Katherine J Franz
Journal:  J Inorg Biochem       Date:  2011-12-03       Impact factor: 4.155

6.  Optical and structural properties of copper-oxytocin dications in the gas phase.

Authors:  Laure Joly; Rodolphe Antoine; Florian Albrieux; Renaud Ballivian; Michel Broyer; Fabien Chirot; Jérôme Lemoine; Philippe Dugourd; Claudio Greco; Roland Mitrić; Vlasta Bonacić-Koutecký
Journal:  J Phys Chem B       Date:  2009-08-13       Impact factor: 2.991

7.  Optical properties of isolated hormone oxytocin dianions: ionization, reduction, and copper complexation effects.

Authors:  Laure Joly; Rodolphe Antoine; Abdul-Rahman Allouche; Michel Broyer; Jérôme Lemoine; Philippe Dugourd
Journal:  J Phys Chem A       Date:  2009-06-18       Impact factor: 2.781

8.  Potentiometric and spectroscopic studies of the Cu(II) complexes of Ala-Arg8-vasopressin and oxytocin: two vasopressin-like peptides.

Authors:  W Bal; H Kozlowski; B Lammek; L D Pettit; K Rolka
Journal:  J Inorg Biochem       Date:  1992-02-15       Impact factor: 4.155

9.  Oxytocin-Monolayer-Based Impedimetric Biosensor for Zinc and Copper Ions.

Authors:  Kiran Kumar Tadi; Israel Alshanski; Evgeniy Mervinetsky; Gerard Marx; Panayiota Petrou; Karussis M Dimitrios; Chaim Gilon; Mattan Hurevich; Shlomo Yitzchaik
Journal:  ACS Omega       Date:  2017-12-08

Review 10.  Copper metabolism as a unique vulnerability in cancer.

Authors:  Vinit C Shanbhag; Nikita Gudekar; Kimberly Jasmer; Christos Papageorgiou; Kamal Singh; Michael J Petris
Journal:  Biochim Biophys Acta Mol Cell Res       Date:  2020-10-20       Impact factor: 4.739
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  1 in total

Review 1.  Role of Oxytocin and Vasopressin in Neuropsychiatric Disorders: Therapeutic Potential of Agonists and Antagonists.

Authors:  Valeska Cid-Jofré; Macarena Moreno; Miguel Reyes-Parada; Georgina M Renard
Journal:  Int J Mol Sci       Date:  2021-11-08       Impact factor: 5.923
  1 in total

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