May Fouad Nassar1, Yasmin Gamal Abdou El-Gendy2, Mohamed Tarif Hamza3, Marwa Nasser Mohamed4, Nesrine Radwan5. 1. Pediatric Clinical Nutrition Unit, Children's Hospital, Ain Shams University, Cairo, Egypt. maie_nassar@yahoo.co.uk. 2. Pediatric Clinical Nutrition Unit, Children's Hospital, Ain Shams University, Cairo, Egypt. 3. Clinical Pathology Department, Ain Shams University, Cairo, Egypt. 4. Ministry of Health Hospitals, Cairo, Egypt. 5. Pediatric Allergy, Immunology and Rheumatology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt.
Abstract
BACKGROUND AND AIM OF THE WORK: Ketogenic diet (KD) is one of the treatments in drug-resistant epilepsy (DRE). The current study aimed at assessing the effect of KD-induced ketosis on different immunological cells since ketosis is reported to affect neutrophil function. METHODOLOGY: We recruited 21 pediatric patients diagnosed with DRE assigned to start KD. Anthropometric measurements, complete blood picture with differential count, phagocytic function, lymphocyte subsets, and IgG estimation were estimated initially and after 6 months of KD. RESULTS: There were no differences between the initial total leucocytic, neutrophil, and lymphocytic counts as well as the lymphocyte subsets, and the values after 6 months of KD. IgG values showed significant increase yet the values were still within the reference ranges. For the innate immune system, the phagocytic index was assessed and it showed a marked statistical reduction in patients after KD. CONCLUSION: KD has no effect on neutrophil and lymphocytic counts as well as the number of adaptive and immune cells; nevertheless, it causes a reduction in phagocytic index in DRE. Accordingly, further detailed study for the full immunological profile and function is needed to ensure the safety of this therapeutic line and correlate it with the clinical history.
BACKGROUND AND AIM OF THE WORK: Ketogenic diet (KD) is one of the treatments in drug-resistant epilepsy (DRE). The current study aimed at assessing the effect of KD-induced ketosis on different immunological cells since ketosis is reported to affect neutrophil function. METHODOLOGY: We recruited 21 pediatric patients diagnosed with DRE assigned to start KD. Anthropometric measurements, complete blood picture with differential count, phagocytic function, lymphocyte subsets, and IgG estimation were estimated initially and after 6 months of KD. RESULTS: There were no differences between the initial total leucocytic, neutrophil, and lymphocytic counts as well as the lymphocyte subsets, and the values after 6 months of KD. IgG values showed significant increase yet the values were still within the reference ranges. For the innate immune system, the phagocytic index was assessed and it showed a marked statistical reduction in patients after KD. CONCLUSION: KD has no effect on neutrophil and lymphocytic counts as well as the number of adaptive and immune cells; nevertheless, it causes a reduction in phagocytic index in DRE. Accordingly, further detailed study for the full immunological profile and function is needed to ensure the safety of this therapeutic line and correlate it with the clinical history.
Authors: D A Fraser; J Thoen; S Bondhus; M Haugen; J E Reseland; O Djøseland; O Førre; J Kjeldsen-Kragh Journal: Clin Exp Rheumatol Date: 2000 Mar-Apr Impact factor: 4.473
Authors: D A J E Lambrechts; R J A de Kinderen; J S H Vles; A J A de Louw; A P Aldenkamp; H J M Majoie Journal: Acta Neurol Scand Date: 2016-03-29 Impact factor: 3.209