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Literature DB >> 3444370

Enzymatic acylation of ether and ester lysophospholipids in rat liver microsomes.

W Neumüller¹, E A Fleer, C Unger, H Eibl.

Abstract

The acylation of lysophospholipids by rat liver acyltransferases was studied. A comparison between ester and ether lysophospholipids as substrates revealed large differences in substrate properties. For instance, oleic acid from oleoyl-CoA and arachidonic acid from arachidonoyl-CoA were not incorporated into 1-O-octadecyl-sn-glycero-3-phosphocholine under experimental conditions that allowed an optimal transfer of oleic acid and arachidonic acid to 1-O-palmitoyl-sn-glycero-3-phosphocholine. However, we observed an acyl-CoA-independent transfer of arachidonic acid from 1-O-stearoyl-2-O-arachidonoyl-sn-glycero-3-phosphoinositol to 1-O-octadecyl-sn-glycero-3-phosphocholine.

Entities: Chemical Species

Mesh：

Substances：

Year: 1987 PMID： 3444370 DOI： 10.1007/BF02535535

Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880

20 in total

1. The enzymatic synthesis of triglycerides.

Authors: S B WEISS; E P KENNEDY; J Y KIYASU
Journal: J Biol Chem Date: 1960-01 Impact factor: 5.157

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Authors: E P KENNEDY
Journal: Fed Proc Date: 1961-12

3. Acyltransferase-catalyzed cleavage of arachidonic acid from phospholipids and transfer to lysophosphatides in macrophages derived from bone marrow. Comparison of different donor- and acceptor substrate combinations.

Authors: I Flesch; B Ecker; E Ferber
Journal: Eur J Biochem Date: 1984-03-15

4. Monooxygenase activity of rat liver microsomes immobilized by entrapment in a crosslinked prepolymerized polyacrylamide hydrazide.

Authors: A Yawetz; A S Perry; A Freeman; E Katchalski-Katzir
Journal: Biochim Biophys Acta Date: 1984-04-10

5. 1-O-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine. A common source of platelet-activating factor and arachidonate in human polymorphonuclear leukocytes.

Authors: F H Chilton; J M Ellis; S C Olson; R L Wykle
Journal: J Biol Chem Date: 1984-10-10 Impact factor: 5.157

6. Arachidonoyl transacylase in human platelets. Coenzyme A-independent transfer of arachidonate from phosphatidylcholine to lysoplasmenylethanolamine.

Authors: R M Kramer; D Deykin
Journal: J Biol Chem Date: 1983-11-25 Impact factor: 5.157

7. Acylation of lysophospholipids by rabbit alveolar macrophages. Specificities of CoA-dependent and CoA-independent reactions.

Authors: M Robinson; M L Blank; F Snyder
Journal: J Biol Chem Date: 1985-07-05 Impact factor: 5.157

8. Formation of diacyl- and alkylacylphosphatidylcholine by the membranes of human platelets.

Authors: M L McKean; M J Silver; K S Authi; N Crawford
Journal: FEBS Lett Date: 1986-01-20 Impact factor: 4.124

9. Cytotoxicity of alkyl-lysophospholipid derivatives and low-alkyl-cleavage enzyme activities in rat brain tumor cells.

Authors: W E Berdel; E Greiner; U Fink; D Stavrou; A Reichert; J Rastetter; D R Hoffman; F Snyder
Journal: Cancer Res Date: 1983-02 Impact factor: 12.701

Review 10. Synthesis of glycerophospholipids.

Authors: H Eibl
Journal: Chem Phys Lipids Date: 1980-06 Impact factor: 3.329

4 in total