Literature DB >> 3443645

Determination of methylprednisolone metabolites in human urine by gas chromatography-mass spectrometry.

G M Rodchenkov1, V P Uralets, V A Semenov.   

Abstract

Methylprednisolone and its metabolites were studied as their methoxyamine-trimethylsilyl derivatives by means of capillary gas chromatography-mass spectrometry. The expected unchanged drug and 11-keto and 20-hydroxy metabolites were found in human urine. The typical metabolites are 6,7-dehydro analogues of the above-mentioned compounds. Characteristic gas chromatographic profiles of urine steroids were obtained. Retention indices and m/z values are presented for methylprednisolone and its main metabolites.

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Year:  1987        PMID： 3443645     DOI： 10.1016/0378-4347(87)80323-7

Source DB:  PubMed          Journal:  J Chromatogr


  2 in total

1.  Gender-based effects on methylprednisolone pharmacokinetics and pharmacodynamics.

Authors:  K H Lew; E A Ludwig; M A Milad; K Donovan; E Middleton; J J Ferry; W J Jusko
Journal:  Clin Pharmacol Ther       Date:  1993-10       Impact factor: 6.875

2.  A preliminary study on urinary excretion patterns of methylprednisolone after oral and intra-articular administration and effect on endogenous glucocorticosteroids profile.

Authors:  Awanish Kumar Upadhyay; Sachin Dubey; Shobha Ahi; Alka Beotra; Akhilesh Bhardwaj; Sangeeta Shukla; Shila Jain
Journal:  Indian J Pharmacol       Date:  2021 Nov-Dec       Impact factor: 1.200
  2 in total

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