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Literature DB >> 3443452

MRL-lpr/lpr mice show an impairment of IgG aggregate removal which relates to parameters of disease activity.

M Field¹, F M Brennan, D McCarthy, P Mumford, R N Maini.

Abstract

MRL-lpr/lpr mice show an age-related impairment in the removal of heat-aggregated IgG (HAGG) from the circulation. The female mice, which have an earlier mortality than their male counterparts, clear HAGG more slowly than the male animals. Delay in clearance of this probe of mononuclear phagocytic system (MPS) function relates directly to high levels of circulating immune complexes (CIC) and to significant renal damage. In addition it relates indirectly to hepatic and splenic uptake of HAGG. MPS saturation plays a significant role in the pathogenesis of the disease seen in MRL-lpr/lpr mice.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 1987 PMID： 3443452 PMCID： PMC1453452

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

20 in total

1. Preparation of iodine-131 labelled human growth hormone of high specific activity.

Authors: W M HUNTER; F C GREENWOOD
Journal: Nature Date: 1962-05-05 Impact factor: 49.962

2. Renal lesions in MRL mice.

Authors: G J Kolaja; P E Fast
Journal: Vet Pathol Date: 1982-11 Impact factor: 2.221

3. MRL mice show an age-related impairment of IgG aggregate removal from the circulation.

Authors: M Field; F M Brennan; R D Melsom; D McCarthy; P Mumford; R N Maini
Journal: Clin Exp Immunol Date: 1985-07 Impact factor: 4.330

4. Primate erythrocyte-immune complex-clearing mechanism.

Authors: J B Cornacoff; L A Hebert; W L Smead; M E VanAman; D J Birmingham; F J Waxman
Journal: J Clin Invest Date: 1983-02 Impact factor: 14.808

5. Abnormal binding of soluble IgG immune complexes to hepatic nonparenchymal cells of autoimmune mice.

Authors: D B Magilavy; T R Hundley; A D Steinberg; D S Finbloom
Journal: J Immunol Date: 1983-12 Impact factor: 5.422

6. Family studies of erythrocyte complement receptor type 1 levels: reduced levels in patients with SLE are acquired, not inherited.

Authors: M J Walport; G D Ross; C Mackworth-Young; J V Watson; N Hogg; P J Lachmann
Journal: Clin Exp Immunol Date: 1985-03 Impact factor: 4.330

2. Differential oxidative modification of proteins in MRL+/+ and MRL/lpr mice: Increased formation of lipid peroxidation-derived aldehyde-protein adducts may contribute to accelerated onset of autoimmune response.

Authors: Gangduo Wang; Hui Li; M Firoze Khan
Journal: Free Radic Res Date: 2012-09-25

2 in total

MRL-lpr/lpr mice show an impairment of IgG aggregate removal which relates to parameters of disease activity.

1. Preparation of iodine-131 labelled human growth hormone of high specific activity.

2. Renal lesions in MRL mice.

3. MRL mice show an age-related impairment of IgG aggregate removal from the circulation.

4. Primate erythrocyte-immune complex-clearing mechanism.

5. Abnormal binding of soluble IgG immune complexes to hepatic nonparenchymal cells of autoimmune mice.

6. Family studies of erythrocyte complement receptor type 1 levels: reduced levels in patients with SLE are acquired, not inherited.

7. Evidence for an immune complex disorder in systemic lupus erythematosus (SLE).

8. Association of circulating retroviral gp70-anti-gp70 immune complexes with murine systemic lupus erythematosus.

9. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains.

10. Complement receptor (CR1) deficiency in erythrocytes from patients with systemic lupus erythematosus.

1. Serological and histological characterization of the new mutant strain of lpr mice, CBA/KlJms-lprcg/lprcg.

2. Differential oxidative modification of proteins in MRL+/+ and MRL/lpr mice: Increased formation of lipid peroxidation-derived aldehyde-protein adducts may contribute to accelerated onset of autoimmune response.