Jizheng Zhao1,2,3, Peter Manza4, Jun Gu5, Huaibo Song6,7,8, Puning Zhuang6,7,8, Fulei Shi6,7,8, Zhengqi Dong6,7,8, Cheng Lu6,7,8, Gene-Jack Wang9, Dongjian He10,11,12. 1. College of Mechanical and Electronic Engineering, Northwest A&F University, Yangling, Shaanxi, China. zhaojizheng@nwsuaf.edu.cn. 2. Key Laboratory of Agricultural Internet of Things, Ministry of Agriculture, Yangling, Shaanxi, China. zhaojizheng@nwsuaf.edu.cn. 3. Shaanxi Key Laboratory of Agricultural Information Perception and Intelligent Service, Yangling, Shaanxi, China. zhaojizheng@nwsuaf.edu.cn. 4. Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA. 5. Department of Endocrinology, The First Affiliated Hospital of Hebei Northern University, Zhangjiakou, Hebei, China. 6. College of Mechanical and Electronic Engineering, Northwest A&F University, Yangling, Shaanxi, China. 7. Key Laboratory of Agricultural Internet of Things, Ministry of Agriculture, Yangling, Shaanxi, China. 8. Shaanxi Key Laboratory of Agricultural Information Perception and Intelligent Service, Yangling, Shaanxi, China. 9. Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA. gene-jack.wang@nih.gov. 10. College of Mechanical and Electronic Engineering, Northwest A&F University, Yangling, Shaanxi, China. hdj168@nwsuaf.edu.cn. 11. Key Laboratory of Agricultural Internet of Things, Ministry of Agriculture, Yangling, Shaanxi, China. hdj168@nwsuaf.edu.cn. 12. Shaanxi Key Laboratory of Agricultural Information Perception and Intelligent Service, Yangling, Shaanxi, China. hdj168@nwsuaf.edu.cn.
Abstract
BACKGROUND: Obesity is associated with brain intrinsic functional reorganization. However, little is known about the BMI-related interhemispheric functional connectivity (IHFC) alterations, and their link with executive function in young healthy adults. METHODS: We examined voxel-mirrored homotopic connectivity (VMHC) patterns in 417 young adults from the Human Connectome Project. Brain regions with significant association between BMI and VMHC were identified using multiple linear regression. Results from these analyses were then used to determine regions for seed-voxel FC analysis, and multiple linear regression was used to explore the brain regions showing significant association between BMI and FC. The correlations between BMI-related executive function measurements and VMHC, as well as seed-voxel FC, were further examined. RESULTS: BMI was negatively associated with scores of Dimensional Change Card Sort Test (DCST) assessing cognitive flexibility (r = -0.14, p = 0.006) and with VMHC of bilateral inferior parietal lobule, insula and dorsal caudate. The dorsal caudate emerged as a nexus for BMI-related findings: greater BMI was associated with greater FC between caudate and hippocampus and lower FC between caudate and several prefrontal nodes (right inferior frontal gyrus, anterior cingulate cortex, and middle frontal gyrus). The FC between right caudate and left hippocampus was negatively associated with scores of DCST (r = -0.15, p = 0.0018). CONCLUSIONS: Higher BMI is associated with poorer cognitive flexibility performance and IHFC in an extensive set of brain regions implicated in cognitive control. Larger BMI was associated with higher caudate-medial temporal lobe FC and lower caudate-dorsolateral prefrontal cortex FC. These findings may have relevance for executive function associated with weight gain among otherwise healthy young adults.
BACKGROUND: Obesity is associated with brain intrinsic functional reorganization. However, little is known about the BMI-related interhemispheric functional connectivity (IHFC) alterations, and their link with executive function in young healthy adults. METHODS: We examined voxel-mirrored homotopic connectivity (VMHC) patterns in 417 young adults from the Human Connectome Project. Brain regions with significant association between BMI and VMHC were identified using multiple linear regression. Results from these analyses were then used to determine regions for seed-voxel FC analysis, and multiple linear regression was used to explore the brain regions showing significant association between BMI and FC. The correlations between BMI-related executive function measurements and VMHC, as well as seed-voxel FC, were further examined. RESULTS: BMI was negatively associated with scores of Dimensional Change Card Sort Test (DCST) assessing cognitive flexibility (r = -0.14, p = 0.006) and with VMHC of bilateral inferior parietal lobule, insula and dorsal caudate. The dorsal caudate emerged as a nexus for BMI-related findings: greater BMI was associated with greater FC between caudate and hippocampus and lower FC between caudate and several prefrontal nodes (right inferior frontal gyrus, anterior cingulate cortex, and middle frontal gyrus). The FC between right caudate and left hippocampus was negatively associated with scores of DCST (r = -0.15, p = 0.0018). CONCLUSIONS: Higher BMI is associated with poorer cognitive flexibility performance and IHFC in an extensive set of brain regions implicated in cognitive control. Larger BMI was associated with higher caudate-medial temporal lobe FC and lower caudate-dorsolateral prefrontal cortex FC. These findings may have relevance for executive function associated with weight gain among otherwise healthy young adults.
Authors: Frauke Beyer; Sharzhad Kharabian Masouleh; Julia M Huntenburg; Leonie Lampe; Tobias Luck; Steffi G Riedel-Heller; Markus Loeffler; Matthias L Schroeter; Michael Stumvoll; Arno Villringer; A Veronica Witte Journal: Hum Brain Mapp Date: 2017-04-11 Impact factor: 5.038
Authors: Isabel García-García; María Ángeles Jurado; Maite Garolera; Idoia Marqués-Iturria; Annette Horstmann; Bàrbara Segura; Roser Pueyo; María José Sender-Palacios; Maria Vernet-Vernet; Arno Villringer; Carme Junqué; Daniel S Margulies; Jane Neumann Journal: Psychiatry Res Date: 2015-06-19 Impact factor: 3.222