Literature DB >> 344332

High-performance liquid chromatographic determination of benzodiazepines in human plasma.

R R Brodie, L F Chasseaud, T Taylor.   

Abstract

A simple and sensitive method for determination of benzodiazepines in plasma has been developed using high-performance liquid chromatography in a reverse-phase mode. The method is illustrated by application to plasma samples containing diazepam and N-desmethyldiazepam at concentrations which would be encountered during therapy, with limits of detection of 10 ng/ml and 2 ng/ml for diazepam and N-desmethyldiazepam, respectively.

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Year:  1978        PMID： 344332     DOI： 10.1016/s0021-9673(00)88195-9

Source DB:  PubMed          Journal:  J Chromatogr


  3 in total

1.  Evaluation of the pharmacokinetic interaction between diazepam and ACC-9653 (a phenytoin prodrug) in healthy male volunteers.

Authors:  E K Hussey; G E Dukes; J A Messenheimer; K L Brouwer; K H Donn; T F Krol; L J Hak
Journal:  Pharm Res       Date:  1990-11       Impact factor: 4.200

2.  A study of the effects of zimelidine on the pharmacokinetics and pharmacodynamics of temazepam in healthy volunteers.

Authors:  D Fagan; D B Scott; B Tiplady
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

3.  Effects of lorazepam on cardiac vagal tone during rest and mental stress: assessment by means of spectral analysis.

Authors:  J H Tulen; G Mulder; L Pepplinkhuizen; A J Man in 't Veld; H G van Steenis; P Moleman
Journal:  Psychopharmacology (Berl)       Date:  1994-02       Impact factor: 4.530
  3 in total

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