A comprehensive chemical and pharmacological review of three confusable Chinese herbal medicine-Aucklandiae radix, Vladimiriae radix, and Inulae radix.

Aucklandiae radix (AR, Muxiang), vladimiriae radix (VR, Chuanmuxiang), and inulae radix (IR, Tumuxiang) are widely used in clinical or folk medicine in China. Their Chinese names all have the Chinese character "Muxiang," which makes it confusable in usage, especially AR and VR, because VR was used as a substitute for AR during a historical period. The National Health Commission of the People's Republic of China has approved AR as a functional food. However, VR and IR are not listed. Many research articles on three kinds of "Muxiang" have been published. However, no review was appeared to compare similarities and differences among the three kinds of "Muxiang." Here, the morphological characterization, phytochemistry, and pharmaceutical effects of AR, VR, and IR were reviewed. We found that only six compounds were common in the three species. Twenty-six compounds were common to AR and VR. Twenty-two compounds were common to AR and IR. Only seven compounds were common to VR and IR. The extracts of AR, VR, and IR were all reported with antiinflammatory effects, which is the most important activity of "Muxiang" species. The volatile oil of AR, VR, and IR had antibacterial activities. Extracts of AR and VR showed anti-gastric ulcers and anti-diarrhea effects. Extracts of AR and IR exhibited anticancer effects. In addition, AR extract had liver protective effect. It is worth mentioning that costunolide and dehydrocostus lactone, which were the common representative compounds of "Muxiang" species, showed antiinflammatory, anticancer, anti-gastric ulcers, and liver protective effects. This review will be a benefit reference for correct understanding and application of the three "Muxiang" species.