Minodora Desmirean1,2, Cedric Richlitzki1, Sergiu Pasca1, Patric Teodorescu1,3, Bobe Petrushev4, Sebastian Rauch1, Jacob Steinheber1, Sabina Iluta3, Jiaxin Liu5, Delia Dima3, Ravnit Grewal6,7,8, Weina Ma9, Liren Qian5, Ciprian Tomuleasa1,3,4. 1. Department of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. 2. Department of Pathology, Constantin Papilian Military Hospital, Cluj-Napoca, Romania. 3. Department of Hematology, Ion Chiricuta Clinical Cancer Center, Cluj-Napoca, Romania. 4. Medfuture Research Center for Advanced Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. 5. Department of Hematology, The Sixth Medical Center of PLA General Hospital, Beijing, China. 6. South African Bioinformatics Institute, University of the Western Cape, Cape Town, South Africa. 7. South African Medical Research Council, Cape Town, South Africa. 8. Department of Hematology and Cell Biology, Faculty of Health Sciences, National Health Laboratory Services, University of the Free State, Bloemfontein, South Africa. 9. Department of Pathology, The Sixth Medical Center of PLA General Hospital, Beijing, China.
Abstract
BACKGROUND AND AIMS: Alcohol is a psychoactive substance that causes dependence, with many thousands of years in the history of mankind, being widely used in different cultures. According to the International Agency for Research on Cancer, alcohol is involved in the development of cancer, being directly associated with it. Considering that alcohol is involved in the initiation and dissemination of gastrointestinal malignancies, the objective of the study was to assess its role in the pathogenesis of T-cell lymphomas, as well as its possible correlation with chronic consumption. METHODS: The patient cohort was compiled from the Sixth Medical Center of the People's Liberation Army Navy General Hospital in Beijing, China. A total of 30 patients matched the criteria and were enrolled in the study. Statistical analysis of the raw data was performed using R Statistics version R 3.5.1. released on the 29.08.2018. RESULTS: Our data demonstrate that the most common extranodal involvment of T-cell lymphoma patients is represented in decreasing order by bone marrow, peritoneum, rhino-oropharynx and the liver-biliary system. Nodal involvement is mainly represented in decreasing order by the laterocervical, axillary, mediastinal and inguinal regions. CONCLUSIONS: These findings may be of value in further research and practical/clinical settings. Fever is the most common clinical feature and was present in most studied patients.
BACKGROUND AND AIMS: Alcohol is a psychoactive substance that causes dependence, with many thousands of years in the history of mankind, being widely used in different cultures. According to the International Agency for Research on Cancer, alcohol is involved in the development of cancer, being directly associated with it. Considering that alcohol is involved in the initiation and dissemination of gastrointestinal malignancies, the objective of the study was to assess its role in the pathogenesis of T-cell lymphomas, as well as its possible correlation with chronic consumption. METHODS: The patient cohort was compiled from the Sixth Medical Center of the People's Liberation Army Navy General Hospital in Beijing, China. A total of 30 patients matched the criteria and were enrolled in the study. Statistical analysis of the raw data was performed using R Statistics version R 3.5.1. released on the 29.08.2018. RESULTS: Our data demonstrate that the most common extranodal involvment of T-cell lymphoma patients is represented in decreasing order by bone marrow, peritoneum, rhino-oropharynx and the liver-biliary system. Nodal involvement is mainly represented in decreasing order by the laterocervical, axillary, mediastinal and inguinal regions. CONCLUSIONS: These findings may be of value in further research and practical/clinical settings. Fever is the most common clinical feature and was present in most studied patients.
Authors: Jürgen Rehm; Shalini Kailasapillai; Elisabeth Larsen; Maximilien X Rehm; Andriy V Samokhvalov; Kevin D Shield; Michael Roerecke; Dirk W Lachenmeier Journal: Addiction Date: 2014-03-03 Impact factor: 6.526