Hirohiko Kuroda 1 , Hiroaki Saito 2 , Yuki Murakami 3 , Yuji Shishido 3 , Kozo Miyatani 3 , Tomoyuki Matsunaga 3 , Yoshiyuki Fujiwara 3 Show Affiliations »
Abstract
BACKGROUND: Postoperative inflammation is associated with cancer progression in several cancers. However, the prognostic significance of postoperative fever remains unclear in gastric cancer patients. METHODS: We enrolled 442 patients with a histopathological diagnosis of gastric adenocarcinoma who underwent curative surgery. RESULTS: The mean duration of postoperative fever ≥ 37°C was 8.7 days (range: 0-186 days) and significantly longer in patients with advanced gastric cancer, venous invasion, and open or total gastrectomy vs. patients with early gastric cancer (P = 0.0072), no venous invasion (P = 0.025), laparoscopic gastrectomy (P = 0.027), and either proximal or distal partial gastrectomy (P = 0.0015). Five-year overall survival rates were 69.5% vs. 83.6% in the prolonged postoperative fever group (≥ 6 days of ≥ 37°C) vs. the nonprolonged group (< 6 days of ≥ 37°C), respectively (P = 0.0008). In patients without Clavien-Dindo classification postoperative infectious complications grade ≥ 2, 5-year overall survival was 69.7% vs. 84.0% in patients with prolonged postoperative fever vs. those without, respectively (P = 0.0067). Five-year disease-specific survival was 85.9% vs. 93.1% in patients with prolonged fever vs. those without, respectively (P = 0.041). Multivariate analysis indicated that postoperative fever was an independent prognostic indicator. CONCLUSION: Postoperative fever ≥ 37°C duration may be useful in predicting prognosis in gastric cancer patients. ©2021 Tottori University Medical Press.
BACKGROUND: Postoperative inflammation is associated with cancer progression in several cancers. However, the prognostic significance of postoperative fever remains unclear in gastric cancer patients. METHODS: We enrolled 442 patients with a histopathological diagnosis of gastric adenocarcinoma who underwent curative surgery. RESULTS: The mean duration of postoperative fever ≥ 37°C was 8.7 days (range: 0-186 days) and significantly longer in patients with advanced gastric cancer, venous invasion, and open or total gastrectomy vs. patients with early gastric cancer (P = 0.0072), no venous invasion (P = 0.025), laparoscopic gastrectomy (P = 0.027), and either proximal or distal partial gastrectomy (P = 0.0015). Five-year overall survival rates were 69.5% vs. 83.6% in the prolonged postoperative fever group (≥ 6 days of ≥ 37°C) vs. the nonprolonged group (< 6 days of ≥ 37°C), respectively (P = 0.0008). In patients without Clavien-Dindo classification postoperative infectious complications grade ≥ 2, 5-year overall survival was 69.7% vs. 84.0% in patients with prolonged postoperative fever vs. those without, respectively (P = 0.0067). Five-year disease-specific survival was 85.9% vs. 93.1% in patients with prolonged fever vs. those without, respectively (P = 0.041). Multivariate analysis indicated that postoperative fever was an independent prognostic indicator. CONCLUSION: Postoperative fever ≥ 37°C duration may be useful in predicting prognosis in gastric cancer patients. ©2021 Tottori University Medical Press.
Entities: Chemical
Keywords:
fever; gastric cancer; prognosis; recurrence
Year: 2021
PMID： 34429704 PMCID： PMC8380549 DOI： 10.33160/yam.2021.08.006
Source DB: PubMed Journal: Yonago Acta Med ISSN： 0513-5710 Impact factor: 1.641