Literature DB >> 3442822

Direct recombinogenic effect of dimethylnitrosamine (DMN) on zygotes of Chlamydomonas reinhardtii.

A Preidel1, O Schimmer.   

Abstract

We developed a test system with mutant strains of Chlamydomonas reinhardtii requiring arginine. Here, the meiotic recombination between two arginine loci served as an indicator of genotoxicity. After crossing, zygotes were treated with the alkylating agent dimethyl-nitrosamine (DMN) for 30 min. A dose dependent increase of wild type recombinants was found for DMN concentrations ranging from 68 microM to 680 microM. Like in cells of some higher plants, the agent was active in Chlamydomonas zygotes without any exogenous metabolic activation.

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Year:  1986        PMID： 3442822     DOI： 10.1007/BF00418412

Source DB:  PubMed          Journal:  Curr Genet        ISSN： 0172-8083            Impact factor:   3.886


  14 in total

1.  [THE EFFECT OF CARCINOGENIC NITROSAMINE AND NITROSAMIDE ON THE ADENINE-6-45 REVERSE MUTATION SYSTEM OF SACCHAROMYCES CEREVISIAE].

Authors:  H MARQUARDT; F K ZIMMERMANN; R SCHWAIER
Journal:  Z Vererbungsl       Date:  1964-04-10

2.  A genetic analysis of linkage group I of Chlamydomonas reinhardi.

Authors:  W T EBERSOLD; R P LEVINE
Journal:  Z Vererbungsl       Date:  1959

3.  The genetics and cytology of Chlamydomonas.

Authors:  R P LEVINE; W T EBERSOLD
Journal:  Annu Rev Microbiol       Date:  1960       Impact factor: 15.500

4.  [Investigations on the mutagenic activity of coumarin derivatives in chlamydomonas. II. Extranuclear mutations induced by xanthotoxin plus near ultraviolet light (author's transl)].

Authors:  O Schimmer
Journal:  Mutat Res       Date:  1977-07       Impact factor: 2.433

5.  Comparison of the genetic activity of dimethylnitrosamine, ethyl methanesulfonate, 2-acetylaminofluorene and ICR-170 in Saccharomyces cerevisiae strains D3, D4 and D5 using in vitro assays with and without metabolic activation.

Authors:  D Brusick; H Andrews
Journal:  Mutat Res       Date:  1974-12       Impact factor: 2.433

6.  The mutagenic activity of nitrosoamines in Arabidopis thaliana.

Authors:  J Velemínský; T Gichner
Journal:  Mutat Res       Date:  1968 May-Jun       Impact factor: 2.433

7.  Deoxyribonucleic acid replication in meiosis of Chlamydomonas reinhardi. I. Isotopic transfer experiments with a strain producing eight zoospores.

Authors:  N Sueoka; K S Chiang; J R Kates
Journal:  J Mol Biol       Date:  1967-04-14       Impact factor: 5.469

8.  Somatic crossing-over in Glycine max (L.) merrill: activation of dimethyl nitrosoamine by plant seed and comparison with methyl nitrosourea in inducing somatic mosaicism.

Authors:  P Arenaz; B K Vig
Journal:  Mutat Res       Date:  1978-12       Impact factor: 2.433

9.  Damage induced by methyl methanesulfonate (MMS) in Chlamydomonas reinhardi.

Authors:  R Loppes
Journal:  Z Vererbungsl       Date:  1966

10.  Gametic differentiation in Chlamydomonas reinhardtii. I. Production of gametes and their fine structure.

Authors:  N C Martin; U W Goodenough
Journal:  J Cell Biol       Date:  1975-12       Impact factor: 10.539
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