Literature DB >> 34427842

PTZ kindling model for epileptogenesis, refractory epilepsy, and associated comorbidities: relevance and reliability.

Tanveer Singh1,2, Awanish Mishra1,3, Rajesh Kumar Goel4.   

Abstract

Pentylenetetrazole (PTZ)-induced seizure is one of the gold standard mouse models for rapid evaluation of novel anticonvulsants. Synchronically, PTZ induced kindling in mice is also a simple and well accepted model of chronic epilepsy. PTZ kindling has been explored for studying epileptogenesis, epilepsy-associated comorbidities, and refractory epilepsy. This review summarizes the potential of PTZ kindling in mice and its modifications for its face, construct, and predictive validity to screen antiepileptogenic drugs, combined or add on novel and safe therapies for treatment of epilepsy-associated depression and cognitive impairment as well as effective interventions for pharmacoresistant epilepsy.
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Cognitive impairment; Depression; Epileptogenesis; Kindling; Pentylenetetrazole; Refractory epilepsy

Mesh：

Substances：

Year:  2021        PMID： 34427842     DOI： 10.1007/s11011-021-00823-3

Source DB:  PubMed          Journal:  Metab Brain Dis        ISSN： 0885-7490            Impact factor:   3.584


  78 in total

1.  The PTZ kindling mouse model of epilepsy exhibits exploratory drive deficits and aberrant activity amongst VTA dopamine neurons in both familiar and novel space.

Authors:  Mahboubeh Ahmadi; Jean-Philippe Dufour; Erich Seifritz; Javad Mirnajafi-Zadeh; Bechara J Saab
Journal:  Behav Brain Res       Date:  2017-05-12       Impact factor: 3.332

2.  Involvement of H2 S, NO and BDNF-TrkB signalling pathway in the protective effects of simvastatin against pentylenetetrazole-induced kindling and cognitive impairments in mice.

Authors:  Marwa A Ahmed; Esam O Kamel
Journal:  Basic Clin Pharmacol Toxicol       Date:  2020-07-28       Impact factor: 4.080

3.  A potential mechanism for the ameliorative effect of thymoquinone on pentylenetetrazole-induced kindling and cognitive impairments in mice.

Authors:  Ahmed O Abdel-Zaher; Hanan S M Farghaly; Magda M Y Farrag; Mahran S Abdel-Rahman; Basel A Abdel-Wahab
Journal:  Biomed Pharmacother       Date:  2017-01-25       Impact factor: 6.529

4.  [Congenital defects].

Authors:  P Aula
Journal:  Duodecim       Date:  1981

5.  Fluvoxamine alleviates seizure activity and downregulates hippocampal GAP-43 expression in pentylenetetrazole-kindled mice: role of 5-HT3 receptors.

Authors:  Momen W Alhaj; Sawsan A Zaitone; Yasser M Moustafa
Journal:  Behav Pharmacol       Date:  2015-06       Impact factor: 2.293

Review 6.  The relevance of kindling for human epilepsy.

Authors:  Edward Bertram
Journal:  Epilepsia       Date:  2007       Impact factor: 5.864

7.  Proconvulsant effects of estriol, the third estrogen, in the mouse PTZ-kindling model.

Authors:  Aakifa Ahmad; Divya Vohora
Journal:  Neurol Sci       Date:  2014-04-19       Impact factor: 3.307

8.  Kainic Acid-Induced Post-Status Epilepticus Models of Temporal Lobe Epilepsy with Diverging Seizure Phenotype and Neuropathology.

Authors:  Daniele Bertoglio; Halima Amhaoul; Annemie Van Eetveldt; Ruben Houbrechts; Sebastiaan Van De Vijver; Idrish Ali; Stefanie Dedeurwaerdere
Journal:  Front Neurol       Date:  2017-11-06       Impact factor: 4.003

9.  Effects of agomelatine on pentylenetetrazole-induced kindling, kindling-associated oxidative stress, and behavioral despair in mice and modulation of its actions by luzindole and 1-(m-chlorophenyl) piperazine.

Authors:  M Suhaib Azim; Nidhi B Agarwal; Divya Vohora
Journal:  Epilepsy Behav       Date:  2017-06-07       Impact factor: 2.937
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  4 in total

1.  Ferulic acid inhibits catamenial epilepsy through modulation of female hormones.

Authors:  Harleen Kaur Dhillon; Tanveer Singh; Rajesh Kumar Goel
Journal:  Metab Brain Dis       Date:  2022-08-06       Impact factor: 3.655

2.  Imatinib Attenuates Pentylenetetrazole Kindled and Pilocarpine Induced Recurrent Spontaneous Seizures in Mice.

Authors:  Shareen Singh; Thakur Gurjeet Singh
Journal:  Neurochem Res       Date:  2022-10-14       Impact factor: 4.414

3.  Up-and-coming anti-epileptic effect of aloesone in Aloe vera: Evidenced by integrating network pharmacological analysis, in vitro, and in vivo models.

Authors:  Yan Wang; Chang Li; Zhongyv Xiong; Niangen Chen; Xuesong Wang; Junyv Xu; Yuemei Wang; Longfeng Liu; Hang Wu; Caihui Huang; Aiqin Huang; Jiajia Tan; Youbin Li; Qifu Li
Journal:  Front Pharmacol       Date:  2022-08-12       Impact factor: 5.988

4.  Ketogenic Diet Alleviates Hippocampal Neurodegeneration Possibly via ASIC1a and the Mitochondria-Mediated Apoptotic Pathway in a Rat Model of Temporal Lobe Epilepsy.

Authors:  Lijing Jia; Weiping Wang; Qi Qiao; Zhenzhen Qu; Shuang Tian; Huifang Cao; Yange Zhang; Can Sun
Journal:  Neuropsychiatr Dis Treat       Date:  2022-09-25       Impact factor: 2.989
  4 in total

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