Xiaowen Wang1,2, Yang Su3, Chao Yang4, Yonghua Hu1, Jia-Yi Dong5. 1. Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, 100191, China. 2. Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Osaka, 5650871, Japan. 3. Department of Urology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450002, China. 4. Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, 100034, China. 5. Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Osaka, 5650871, Japan. dongjy@mail3.sysu.edu.cn.
Abstract
PURPOSE: To examine the prospective association of BPH with subsequent risk of CVD, including heart disease and stroke. METHODS: We used data from China Health and Retirement Longitudinal Study of 5242 Chinese men aged 45 years or older. During a follow-up of 7 years, we identified 613 cases of non-fatal CVD, including 417 heart diseases and 254 strokes. Cox proportional hazards models yielded hazard ratios (HRs) relating BPH to CVD, heart disease, and stroke incidence. RESULTS: Overall, 8.1% of men reported a history of BPH diagnosed by physicians at baseline. As compared with men without a history of BPH, those reporting a history of BPH had an increased risk of developing CVD (multivariable-adjusted HR = 1.43 [1.12, 1.83], heart disease (1.35 [1.00, 1.83]), and stroke (1.50 [1.03, 2.19]). The subgroup analysis by age at baseline (< 60 vs. ≥ 60 years) showed that the associations appeared to be evident among men < 60 years, particularly for CVD (1.82 [1.24, 2.69]) and heart disease (1.72 [1.06, 2.79]). However, interaction tests suggested the associations were not significantly modified by age (P for interaction > 0.10 for all outcomes). CONCLUSION: In Chinese men, BPH was associated with higher risks of CVD, heart disease and stroke, particularly among men aged < 60 years.
PURPOSE: To examine the prospective association of BPH with subsequent risk of CVD, including heart disease and stroke. METHODS: We used data from China Health and Retirement Longitudinal Study of 5242 Chinese men aged 45 years or older. During a follow-up of 7 years, we identified 613 cases of non-fatal CVD, including 417 heart diseases and 254 strokes. Cox proportional hazards models yielded hazard ratios (HRs) relating BPH to CVD, heart disease, and stroke incidence. RESULTS: Overall, 8.1% of men reported a history of BPH diagnosed by physicians at baseline. As compared with men without a history of BPH, those reporting a history of BPH had an increased risk of developing CVD (multivariable-adjusted HR = 1.43 [1.12, 1.83], heart disease (1.35 [1.00, 1.83]), and stroke (1.50 [1.03, 2.19]). The subgroup analysis by age at baseline (< 60 vs. ≥ 60 years) showed that the associations appeared to be evident among men < 60 years, particularly for CVD (1.82 [1.24, 2.69]) and heart disease (1.72 [1.06, 2.79]). However, interaction tests suggested the associations were not significantly modified by age (P for interaction > 0.10 for all outcomes). CONCLUSION: In Chinese men, BPH was associated with higher risks of CVD, heart disease and stroke, particularly among men aged < 60 years.
Authors: Inge I Bouwman; Marco H Blanker; Boris W V Schouten; Arthur M Bohnen; Rien J M Nijman; Wouter K van der Heide; J L H Ruud Bosch Journal: World J Urol Date: 2014-09-25 Impact factor: 4.226
Authors: Clemens Wehrberger; Christian Temml; Georg Gutjahr; Ingrid Berger; Michael Rauchenwald; Anton Ponholzer; Stephan Madersbacher Journal: Urology Date: 2011-09-09 Impact factor: 2.649
Authors: Mauro Gacci; Giovanni Corona; Arcangelo Sebastianelli; Sergio Serni; Cosimo De Nunzio; Mario Maggi; Linda Vignozzi; Giacomo Novara; Kevin T McVary; Steven A Kaplan; Stavros Gravas; Christopher Chapple Journal: Eur Urol Date: 2016-07-20 Impact factor: 20.096