Prathap Jayaram1,2, Gu Eon Kang3, Brett L Heldt4, Olumide Sokunbi4, Bo Song1, Peter C Yeh1, Max Epstein1, Theodore B Shybut2, Brendan H Lee5, Bijan Najafi3. 1. H Ben Taub Department of Physical Medicine & Rehabilitation, Baylor College of Medicine, Houston, TX 77030, USA. 2. Department of Orthopedic Surgery, Baylor College of Medicine, Houston, TX 77030, USA. 3. Department of Surgery, Interdisciplinary Consortium on Advanced Motion Performance (iCAMP), Baylor College of Medicine, Houston, TX 77030, USA. 4. School of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. 5. Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Abstract
Background: Leukocyte-rich platelet-rich plasma (LR-PRP) has demonstrated to be beneficial for patients with knee osteoarthritis (KOA); however, reliable objective end points to accurately assess its therapeutic effects is lacking. Aim: To investigate the efficacy of LR-PRP as assessed by functional and patient-reported outcomes at early time points (6 weeks). Materials & methods: We conducted a prospective cohort study in 12 patients with diagnosed KOA (Kellgren Lawrence score of II-III), who underwent a single ultrasound-guided LR-PRP injection. Results: There was significant improvement in timed up and go, pain and quality of life scales and balance parameters. There were nonsignificant improvements in range of motion and gait parameters. Conclusion: LR-PRP demonstrates efficacy in meaningful end points for functional and patient-reported outcomes at early time points in patients with KOA.
Background: Leukocyte-rich platelet-rich plasma (LR-PRP) has demonstrated to be beneficial for patients with knee osteoarthritis (KOA); however, reliable objective end points to accurately assess its therapeutic effects is lacking. Aim: To investigate the efficacy of LR-PRP as assessed by functional and patient-reported outcomes at early time points (6 weeks). Materials & methods: We conducted a prospective cohort study in 12 patients with diagnosed KOA (Kellgren Lawrence score of II-III), who underwent a single ultrasound-guided LR-PRP injection. Results: There was significant improvement in timed up and go, pain and quality of life scales and balance parameters. There were nonsignificant improvements in range of motion and gait parameters. Conclusion: LR-PRP demonstrates efficacy in meaningful end points for functional and patient-reported outcomes at early time points in patients with KOA.
Entities:
Keywords:
balance; functional outcomes; gait; knee injury and osteoarthritis outcome score 12; knee osteoarthritis; leukocyte-rich platelet-rich plasma; patient-reported outcomes; timed up and go; wearable sensor technology
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