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Literature DB >> 34423277

Pharmacological Functionalization of Protein-Based Nanorobots as a Novel Tool for Drug Delivery in Cancer.

Abstract

The delivery of hydrophobic therapeutic agents to tumors is a challenge in the treatment of cancers. Here, we review recent advances in coiled-coil protein origami and discuss a proposed programmable protein origami structure, switchable by a protein kinase A/phosphatase switch, as an example of functionalization for designing future protein nanorobots.

Entities: Chemical

Year: 2021 PMID： 34423277 PMCID： PMC8369664 DOI： 10.1021/acsptsci.1c00128

Source DB: PubMed Journal: ACS Pharmacol Transl Sci ISSN： 2575-9108

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References

12 in total

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Journal: Nat Biotechnol Date: 2017-10-16 Impact factor: 54.908

Pharmacological Functionalization of Protein-Based Nanorobots as a Novel Tool for Drug Delivery in Cancer.

1. Effect of phosphorylation on alpha-helix stability as a function of position.

2. Design of a leucine zipper coiled coil stabilized 1.4 kcal mol-1 by phosphorylation of a serine in the e position.

3. Coiled coil peptides and polymer-peptide conjugates: synthesis, self-assembly, characterization and potential in drug delivery systems.

Review 4. Protein Regulation in Signal Transduction.

5. Design of coiled-coil protein-origami cages that self-assemble in vitro and in vivo.

Review 6. Coiled coil protein origami: from modular design principles towards biotechnological applications.

7. Design of a single-chain polypeptide tetrahedron assembled from coiled-coil segments.

8. A thermodynamic scale for leucine zipper stability and dimerization specificity: e and g interhelical interactions.

9. Lipid-peptide vesicle nanoscale hybrids for triggered drug release by mild hyperthermia in vitro and in vivo.

Review 10. Targeting protein kinase A in cancer therapy: an update.