| Literature DB >> 34422205 |
Jane A Leopold1, Steven M Kawut2, Micheala A Aldred3, Stephen L Archer4, Ray L Benza5, Michael R Bristow6, Evan L Brittain7, Naomi Chesler8, Frances S DeMan9, Serpil C Erzurum10, Mark T Gladwin11, Paul M Hassoun12, Anna R Hemnes13, Tim Lahm3, Joao A C Lima13, Joseph Loscalzo1, Bradley A Maron14, Laura Mercer Rosa15, John H Newman13, Susan Redline16, Stuart Rich17, Franz Rischard18, Lissa Sugeng19, W H Wilson Tang20, Ryan J Tedford21, Emily J Tsai22, Corey E Ventetuolo23, YouYang Zhou24, Neil R Aggarwal25, Lei Xiao25.
Abstract
Right ventricular dysfunction is a hallmark of advanced pulmonary vascular, lung parenchymal, and left heart disease, yet the underlying mechanisms that govern (mal)adaptation remain incompletely characterized. Owing to the knowledge gaps in our understanding of the right ventricle (RV) in health and disease, the National Heart, Lung, and Blood Institute (NHLBI) commissioned a working group to identify current challenges in the field. These included a need to define and standardize normal RV structure and function in populations; access to RV tissue for research purposes and the development of complex experimental platforms that recapitulate the in vivo environment; and the advancement of imaging and invasive methodologies to study the RV within basic, translational, and clinical research programs. Specific recommendations were provided, including a call to incorporate precision medicine and innovations in prognosis, diagnosis, and novel RV therapeutics for patients with pulmonary vascular disease.Entities:
Mesh：
Year: 2021 PMID： 34422205 PMCID： PMC8375628 DOI： 10.1161/CIRCHEARTFAILURE.120.007975
Source DB: PubMed Journal: Circ Heart Fail ISSN： 1941-3289 Impact factor: 10.447