| Literature DB >> 344222 |
Abstract
Germfree rats were found to be more susceptible to intravenous challenge with Candida albicans than were conventional rats. The resistance of conventional rats could be overcome by increasing the challenge dose. The resistance of the germfree rat was enhanced by vaccination with Formalin-killed C. albicans in complete Freund adjuvant, complete Freund adjuvant, or incomplete Freund adjuvant. These results, and histological evidence obtained from infected gnotobiotic rats, provided further information on the mechanism of resistance to the disseminated form of candidiasis.Entities:
Mesh:
Substances:
Year: 1978 PMID: 344222 PMCID: PMC414141 DOI: 10.1128/iai.19.2.737-740.1978
Source DB: PubMed Journal: Infect Immun ISSN: 0019-9567 Impact factor: 3.441