Literature DB >> 34420855

Pericytic porters: helping leptin step in.

Daniel J Torres1, Matthew W Pitts2.   

Abstract

A new mechanism of leptin extravasation from the bloodstream into the brain may have been discovered. According to recent findings by Butiaeva et al., pericytes within the blood-brain barrier (BBB) express the leptin receptor and, upon activation, facilitate the movement of the appetite-suppressing hormone into deeper regions of the hypothalamus.
Copyright © 2021 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  blood–brain barrier; hypothalamus; leptin; obesity; pericyte

Mesh：

Substances：

Year:  2021        PMID： 34420855      PMCID： PMC8764624          DOI： 10.1016/j.tem.2021.08.001

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  9 in total

1.  Endothelial Adora2a Activation Promotes Blood-Brain Barrier Breakdown and Cognitive Impairment in Mice with Diet-Induced Insulin Resistance.

Authors:  Masaki Yamamoto; De-Huang Guo; Caterina M Hernandez; Alexis M Stranahan
Journal:  J Neurosci       Date:  2019-03-18       Impact factor: 6.167

2.  Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain.

Authors:  Julie Dam; Fanny Langlet; Emilie Caron; Sophie Steculorum; Eglantine Balland; Andrea Messina; S Rasika; Anthony Falluel-Morel; Youssef Anouar; Bénédicte Dehouck; Eric Trinquet; Ralf Jockers; Sebastien G Bouret; Vincent Prévot
Journal:  Cell Metab       Date:  2014-02-04       Impact factor: 27.287

3.  Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats.

Authors:  B Burguera; M E Couce; G L Curran; M D Jensen; R V Lloyd; M P Cleary; J F Poduslo
Journal:  Diabetes       Date:  2000-07       Impact factor: 9.461

4.  Prostaglandin E₂-induced intercellular adhesion molecule-1 expression is mediated by cAMP/Epac signalling modules in bEnd.3 brain endothelial cells.

Authors:  Tae Yeop Park; Eun Joo Baik; Soo Hwan Lee
Journal:  Br J Pharmacol       Date:  2013-06       Impact factor: 8.739

Review 5.  Leptin and the endocrine control of energy balance.

Authors:  Jeffrey M Friedman
Journal:  Nat Metab       Date:  2019-08-12

6.  A molecular census of arcuate hypothalamus and median eminence cell types.

Authors:  John N Campbell; Evan Z Macosko; Henning Fenselau; Tune H Pers; Anna Lyubetskaya; Danielle Tenen; Melissa Goldman; Anne M J Verstegen; Jon M Resch; Steven A McCarroll; Evan D Rosen; Bradford B Lowell; Linus T Tsai
Journal:  Nat Neurosci       Date:  2017-02-06       Impact factor: 24.884

7.  Tanycyte-Independent Control of Hypothalamic Leptin Signaling.

Authors:  Sooyeon Yoo; David Cha; Dong Won Kim; Thanh V Hoang; Seth Blackshaw
Journal:  Front Neurosci       Date:  2019-03-19       Impact factor: 4.677

Review 8.  Molecular and anatomical determinants of central leptin resistance.

Authors:  Heike Münzberg; Martin G Myers
Journal:  Nat Neurosci       Date:  2005-05       Impact factor: 24.884

9.  Leptin receptor-expressing pericytes mediate access of hypothalamic feeding centers to circulating leptin.

Authors:  Liliia I Butiaeva; Tal Slutzki; Hannah E Swick; Clément Bourguignon; Sarah C Robins; Xiaohong Liu; Kai-Florian Storch; Maia V Kokoeva
Journal:  Cell Metab       Date:  2021-06-14       Impact factor: 27.287
  9 in total
  1 in total

1.  Leptin Promotes Angiogenesis via Pericyte STAT3 Pathway upon Intracerebral Hemorrhage.

Authors:  Qi Cui; Yingmei Zhang; Ning Tian; Jiaxin Yang; Dongshan Ya; Wenjing Xiang; Zixian Zhou; Yanlin Jiang; Jungang Deng; Bin Yang; Xiaohui Lin; Qinghua Li; Rujia Liao
Journal:  Cells       Date:  2022-09-03       Impact factor: 7.666
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.