Wenyu Zhang1,2, Dalong Yin3,4, Xiaoxia Chen5, Shugeng Zhang3,4, Fanzheng Meng4, Hongrui Guo4, Shuhang Liang4, Shuo Zhou4, Shuxun Liu4, Linmao Sun4, Xiao Guo4, Huoling Luo1, Baochun He1, Deqiang Xiao1, Wei Cai4, Chihua Fang6, Lianxin Liu2,3, Fucang Jia1,7. 1. Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences. 2. Department of Surgery, Shenzhen Second People's Hospital, Shenzhen. 3. Department of General Surgery, The First Affiliated Hospital, Division of Life Sciences and Medicine, University of Science and Technology. 4. Department of Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin. 5. Department of Radiology, The Third Medical Center, Chinese PLA General Hospital, Beijing. 6. Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University. 7. Pazhou Lab, Guangzhou, China.
Abstract
BACKGROUND: Clinically, the total and residual liver volume must be accurately calculated before major hepatectomy. However, liver volume might be influenced by pneumoperitoneum during surgery. Changes in liver volume change also affect the accuracy of simulation and augmented reality navigation systems, which are commonly first validated in animal models. In this study, the morphologic changes in porcine livers in vivo under 13 mm Hg pneumoperitoneum pressure were investigated. MATERIALS AND METHODS: Twenty male pigs were scanned with contrast-enhanced computed tomography without pneumoperitoneum and with 13 mm Hg pneumoperitoneum pressure. RESULTS: The surface area and volume of the liver and the vascular diameter of the aortic lumen, inferior vena cava lumen, and portal vein lumen were measured. There were statistically significant differences in the surface area and volume of the liver (P=0.000), transverse diameter of the portal vein (P=0.038), longitudinal diameter of the inferior vena cava (P=0.033), longitudinal diameter of the portal vein (P=0.036), vascular cross-sectional area of the inferior vena cava (P=0.028), and portal vein (P=0.038) before and after 13 mm Hg pneumoperitoneum pressure. CONCLUSIONS: This study indicated that the creation of pneumoperitoneum at 13 mm Hg pressure in a porcine causes liver morphologic alterations affecting the area and volume, as well as the diameter of a blood vessel.
BACKGROUND: Clinically, the total and residual liver volume must be accurately calculated before major hepatectomy. However, liver volume might be influenced by pneumoperitoneum during surgery. Changes in liver volume change also affect the accuracy of simulation and augmented reality navigation systems, which are commonly first validated in animal models. In this study, the morphologic changes in porcine livers in vivo under 13 mm Hg pneumoperitoneum pressure were investigated. MATERIALS AND METHODS: Twenty male pigs were scanned with contrast-enhanced computed tomography without pneumoperitoneum and with 13 mm Hg pneumoperitoneum pressure. RESULTS: The surface area and volume of the liver and the vascular diameter of the aortic lumen, inferior vena cava lumen, and portal vein lumen were measured. There were statistically significant differences in the surface area and volume of the liver (P=0.000), transverse diameter of the portal vein (P=0.038), longitudinal diameter of the inferior vena cava (P=0.033), longitudinal diameter of the portal vein (P=0.036), vascular cross-sectional area of the inferior vena cava (P=0.028), and portal vein (P=0.038) before and after 13 mm Hg pneumoperitoneum pressure. CONCLUSIONS: This study indicated that the creation of pneumoperitoneum at 13 mm Hg pressure in a porcine causes liver morphologic alterations affecting the area and volume, as well as the diameter of a blood vessel.
Authors: Antonio Gangemi; Betty Chang; Paolo Bernante; Gilberto Poggioli Journal: Int J Environ Res Public Health Date: 2021-12-03 Impact factor: 3.390