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Literature DB >> 34415549

Expression of Linear and Circular lncRNAs in Alzheimer's Disease.

Soudeh Ghafouri-Fard¹, Mohammadreza Safari², Mohammad Taheri³, Mohammad Samadian⁴.

Abstract

Alzheimer's disease is a neurodegenerative disorder of the elderly described by progressive cognitive debility. Recent studies have displayed the significance of linear and circular long non-coding RNAs (lncRNAs) in the pathobiology of Alzheimer's disease. These studies have reported the downregulation of MALAT1, while the upregulation of NEAT1, RP11-543N12.1, SOX21-AS1, BDNF-AS, BACE1-AS, ANRIL, XIST, and some other linear lncRNAs in clinical samples are obtained from these patients or animal models of Alzheimer's disease. A number of circRNAs such as ciRS-7, ciRS-7, circNF1-419, circHDAC9, circ_0000950,and circAβ-a have been shown to partake in the pathogenesis of this disorder. In the present manuscript, we provide a review of the impact of linear and circular lncRNAs in the pathobiology of Alzheimer's disease and their potential application as markers for this neurodegenerative condition.

Entities: Chemical

Keywords: Alzheimer’s disease; Expression; circRNA; lncRNA

Mesh：

Substances：

Year: 2021 PMID： 34415549 DOI： 10.1007/s12031-021-01900-z

Source DB: PubMed Journal: J Mol Neurosci ISSN： 0895-8696 Impact factor: 3.444

36 in total

1. Regulatory effects of the long non‑coding RNA RP11‑543N12.1 and microRNA‑324‑3p axis on the neuronal apoptosis induced by the inflammatory reactions of microglia.

Authors: Miao Cai; Yan-Wen Wang; Shan-Hu Xu; Song Qiao; Qin-Fen Shu; Jian-Zong Du; Ya-Guo Li; Xiao-Li Liu
Journal: Int J Mol Med Date: 2018-06-20 Impact factor: 4.101

2. Long Non-Coding RNA BACE1-AS Modulates Isoflurane-Induced Neurotoxicity to Alzheimer's Disease Through Sponging miR-214-3p.

Authors: Wei He; Songyuan Chi; Xing Jin; Jieyu Lu; Wei Zheng; Jie Yan; Duo Zhang
Journal: Neurochem Res Date: 2020-07-17 Impact factor: 3.996

3. Long Noncoding RNA EBF3-AS Promotes Neuron Apoptosis in Alzheimer's Disease.

Authors: Cheng Gu; Cheng Chen; Ruipeng Wu; Tong Dong; Xiaojuan Hu; Yuping Yao; Yi Zhang
Journal: DNA Cell Biol Date: 2018-01-03 Impact factor: 3.311

Review 4. Toward Alzheimer therapies based on genetic knowledge.

Authors: John Hardy
Journal: Annu Rev Med Date: 2004 Impact factor: 13.739

5. Plasma long non-coding RNA BACE1 as a novel biomarker for diagnosis of Alzheimer disease.

Authors: Liang Feng; Yu-Ting Liao; Jin-Cai He; Cheng-Long Xie; Si-Yan Chen; Hui-Hui Fan; Zhi-Peng Su; Zhen Wang
Journal: BMC Neurol Date: 2018-01-09 Impact factor: 2.474

6. Identification of Differentially Expressed Profiles of Alzheimer's Disease Associated Circular RNAs in a Panax Notoginseng Saponins-Treated Alzheimer's Disease Mouse Model.

Authors: Jin-Lan Huang; Zhe-Hao Xu; Si-Man Yang; Chao Yu; Fan Zhang; Mei-Chun Qin; Yan Zhou; Zhen-Guo Zhong; Deng-Pan Wu
Journal: Comput Struct Biotechnol J Date: 2018-11-14 Impact factor: 7.271

7. Long Noncoding RNA NEAT1 Aggravates Aβ-Induced Neuronal Damage by Targeting miR-107 in Alzheimer's Disease.

Authors: Sha Ke; Zhaohui Yang; Fei Yang; Xiaoming Wang; Juan Tan; Bo Liao
Journal: Yonsei Med J Date: 2019-07 Impact factor: 2.759

8. LncRNA RPPH1 attenuates Aβ_25-35-induced endoplasmic reticulum stress and apoptosis in SH-SY5Y cells via miR-326/PKM2.

Authors: Ran Gu; Rui Liu; Lu Wang; Man Tang; Shi-Rong Li; Xiao Hu
Journal: Int J Neurosci Date: 2020-04-26 Impact factor: 2.292

Review 9. Stress Granules and Neurodegenerative Disorders: A Scoping Review.

Authors: Mohammad Reza Asadi; Marziyeh Sadat Moslehian; Hani Sabaie; Abbas Jalaiei; Soudeh Ghafouri-Fard; Mohammad Taheri; Maryam Rezazadeh
Journal: Front Aging Neurosci Date: 2021-06-23 Impact factor: 5.750

10. Depletion of LncRNA NEAT1 Rescues Mitochondrial Dysfunction Through NEDD4L-Dependent PINK1 Degradation in Animal Models of Alzheimer's Disease.

Authors: Zhonghua Huang; Jing Zhao; Wei Wang; Jun Zhou; Jie Zhang
Journal: Front Cell Neurosci Date: 2020-02-19 Impact factor: 5.505

2 in total

Review 1. Context-Dependent Regulation of Gene Expression by Non-Canonical Small RNAs.

Authors: Kinga Plawgo; Katarzyna Dorota Raczynska
Journal: Noncoding RNA Date: 2022-04-29

2. Analysis of ROQUIN, Tristetraprolin (TTP), and BDNF/miR-16/TTP regulatory axis in late onset Alzheimer's disease.

Authors: Mohammad Reza Asadi; Mahnaz Talebi; Jalal Gharesouran; Hani Sabaie; Abbas Jalaiei; Shahram Arsang-Jang; Mohammad Taheri; Arezou Sayad; Maryam Rezazadeh
Journal: Front Aging Neurosci Date: 2022-08-09 Impact factor: 5.702

2 in total