Marissa L Hughbanks1,2, Francisco Rodriguez-Fontan2, Christopher J Kleck2,3, Evalina Burger-Van der Walt2,3. 1. School of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA. 2. Department of Orthopedics, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA. 3. The Spine Center at University of Colorado Hospital, Aurora, CO, USA.
Abstract
OBJECTIVE: Estrogen and osteoarthritis association has previously been proposed. This study evaluates the presence of estrogen receptors (ER)-α in articular cartilage, and its association. METHODS: A prospective cohort study of women undergoing anterior cruciate ligament reconstruction (controls) or total knee arthroplasty (cases) was performed. Cartilage samples were processed and ER-α expression was quantified. RESULTS: Twenty patients were included: 12 cases and 8 controls. ER-α expression was higher in the case subjects. CONCLUSION: Increased ER-α expression is associated with age, and degeneration. This suggests estrogen deficiency is a risk for osteoarthritis and is inversely related to proliferative looking chondrocytes.
OBJECTIVE: Estrogen and osteoarthritis association has previously been proposed. This study evaluates the presence of estrogen receptors (ER)-α in articular cartilage, and its association. METHODS: A prospective cohort study of women undergoing anterior cruciate ligament reconstruction (controls) or total knee arthroplasty (cases) was performed. Cartilage samples were processed and ER-α expression was quantified. RESULTS: Twenty patients were included: 12 cases and 8 controls. ER-α expression was higher in the case subjects. CONCLUSION: Increased ER-α expression is associated with age, and degeneration. This suggests estrogen deficiency is a risk for osteoarthritis and is inversely related to proliferative looking chondrocytes.
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