| Literature DB >> 34413139 |
Adrian Gervais1,2, Tom Le Voyer1,2, Jérémie Rosain1,2, Quentin Philippot1,2, Jérémy Manry1,2, Eleftherios Michailidis3, Hans-Heinrich Hoffmann3, Shohei Eto4, Marina Garcia-Prat5, Lucy Bizien1,2, Alba Parra-Martínez5, Rui Yang6, Liis Haljasmägi7, Mélanie Migaud1,2, Karita Särekannu7, Julia Maslovskaja7, Evangelos Vandreakos8, Olivier Hermine2,9, Aurora Pujol10, Pärt Peterson7, Trine H Mogensen11,12, Lee Rowen13, James Mond14, Xavier de Lamballerie15, Xavier Duval16,17,18,19, France Mentré16,17,18, Marie Zins20, Pere Soler-Palacin5, Roger Colobran21, Guy Gorochov22,23, Xavier Solanich24, Sophie Susen25, Javier Martinez-Picado26,27,28, Didier Raoult29,30, Marc Vasse31, Peter K Gregersen32, Lorenzo Piemonti33, Carlos Rodríguez-Gallego34,35, Luigi D Notarangelo36, Helen C Su36,37, Kai Kisand7, Satoshi Okada4, Anne Puel1,2,6, Emmanuelle Jouanguy1,2,6, Charles M Rice3, Pierre Tiberghien38,39, Qian Zhang1,2,6, Aurélie Cobat1,2,6, Laurent Abel1,2,6, Jean-Laurent Casanova40,2,6,41, Paul Bastard40,2,6, Nicolas de Prost42,43, Yacine Tandjaoui-Lambiotte44, Charles-Edouard Luyt45,46, Blanca Amador-Borrero47, Alexandre Gaudet48,49,50,51,52, Julien Poissy48,49,50,51,52, Pascal Morel38,39, Pascale Richard38, Fabrice Cognasse53,54, Jesus Troya55, Sophie Trouillet-Assant56, Alexandre Belot57,58, Kahina Saker57, Pierre Garçon59, Jacques G Rivière5, Jean-Christophe Lagier29,30, Stéphanie Gentile60,61, Lindsey B Rosen36, Elana Shaw36, Tomohiro Morio62, Junko Tanaka63, David Dalmau64, Pierre-Louis Tharaux65, Damien Sene47, Alain Stepanian66, Bruno Megarbane67, Vasiliki Triantafyllia68, Arnaud Fekkar1,69, James R Heath13, José Luis Franco70, Juan-Manuel Anaya71, Jordi Solé-Violán72,73, Luisa Imberti74, Andrea Biondi75, Paolo Bonfanti76, Riccardo Castagnoli36,77, Ottavia M Delmonte36, Yu Zhang36,78, Andrew L Snow79, Steven M Holland36, Catherine Biggs80, Marcela Moncada-Vélez6, Andrés Augusto Arias6,81,82, Lazaro Lorenzo1,2, Soraya Boucherit1,2, Boubacar Coulibaly1,2, Dany Anglicheau83, Anna M Planas84,85, Filomeen Haerynck86, Sotirija Duvlis87,88, Robert L Nussbaum89, Tayfun Ozcelik90, Sevgi Keles91, Ahmed A Bousfiha92, Jalila El Bakkouri92, Carolina Ramirez-Santana70,71, Stéphane Paul93, Qiang Pan-Hammarström94, Lennart Hammarström94, Annabelle Dupont25, Alina Kurolap95, Christine N Metz32, Alessandro Aiuti96, Giorgio Casari96, Vito Lampasona33, Fabio Ciceri97, Lucila A Barreiros98, Elena Dominguez-Garrido99, Mateus Vidigal100, Mayana Zatz100, Diederik van de Beek101, Sabina Sahanic102, Ivan Tancevski102, Yurii Stepanovskyy103, Oksana Boyarchuk104, Yoko Nukui105, Miyuki Tsumura4, Loreto Vidaur106,107, Stuart G Tangye108, Sonia Burrel109, Darragh Duffy110, Lluis Quintana-Murci111,112, Adam Klocperk113, Nelli Y Kann114, Anna Shcherbina114, Yu-Lung Lau115, Daniel Leung115, Matthieu Coulongeat116, Julien Marlet117,118, Rutger Koning101, Luis Felipe Reyes119,120, Angélique Chauvineau-Grenier121, Fabienne Venet122,123, Guillaume Monneret122,123, Michel C Nussenzweig124,41, Romain Arrestier42,43, Idris Boudhabhay83, Hagit Baris-Feldman95,125, David Hagin125,126, Joost Wauters127, Isabelle Meyts128,129, Adam H Dyer130, Sean P Kennelly130, Nollaig M Bourke131, Rabih Halwani132, Narjes Saheb Sharif-Askari132, Karim Dorgham22, Jérome Sallette133, Souad Mehlal Sedkaoui133, Suzan AlKhater134,135, Raúl Rigo-Bonnin136, Francisco Morandeira137, Lucie Roussel138,139, Donald C Vinh138,139, Sisse Rye Ostrowski140, Antonio Condino-Neto98, Carolina Prando141, Anastasiia Bonradenko103, András N Spaan6,142, Laurent Gilardin143,144, Jacques Fellay145,146,147, Stanislas Lyonnet148, Kaya Bilguvar149,150,151,152, Richard P Lifton149,150,153, Shrikant Mane150, Mark S Anderson154, Bertrand Boisson1,2,6, Vivien Béziat1,2, Shen-Ying Zhang1,2,6, Stéphanie Debette155,156.
Abstract
Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found in about 10% of patients with critical COVID-19 pneumonia, but not in subjects with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or -ω (100 pg/mL, in 1/10 dilutions of plasma) in 13.6% of 3,595 patients with critical COVID-19, including 21% of 374 patients > 80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1,124 deceased patients (aged 20 days-99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β. We also show, in a sample of 34,159 uninfected subjects from the general population, that auto-Abs neutralizing high concentrations of IFN-α and/or -ω are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of subjects carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals <70 years, 2.3% between 70 and 80 years, and 6.3% >80 years. By contrast, auto-Abs neutralizing IFN-β do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over-80s, and total fatal COVID-19 cases.Entities:
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Year: 2021 PMID： 34413139 PMCID： PMC8521484 DOI： 10.1126/sciimmunol.abl4340
Source DB: PubMed Journal: Sci Immunol ISSN： 2470-9468