Literature DB >> 3441311

An adenosine analogue, 2-chloroadenosine, protects against long term development of ischaemic cell loss in the rat hippocampus.

M C Evans1, J H Swan, B S Meldrum.   

Abstract

Delayed ischaemic damage was assessed by light microscopy following 10 min of incomplete forebrain ischaemia and 7 days of reperfusion. Iterative focal injections of 2-chloroadenosine, a stable analogue of adenosine, protect against selective hippocampal CA1 loss (P less than 0.01), when given either immediately before ischaemia and after 4 and 10 h of reperfusion or after 1 min, 4 h and 10 h of reperfusion. Delayed focal injection of 2-chloroadenosine after 10 and 24 h of reperfusion fails to protect against CA1 cell loss. The mechanism of cerebroprotection may involve attenuation of excitatory neurotransmission.

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Year:  1987        PMID： 3441311     DOI： 10.1016/0304-3940(87)90101-7

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  21 in total

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Authors:  J W Phillis; M H O'Regan
Journal:  Neurochem Res       Date:  1996-03       Impact factor: 3.996

Review 2.  Purines and neuronal excitability: links to the ketogenic diet.

Authors:  S A Masino; M Kawamura; D N Ruskin; J D Geiger; D Boison
Journal:  Epilepsy Res       Date:  2011-08-30       Impact factor: 3.045

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Authors:  Kenneth A Jacobson; Hea O Kim; Suhaib M Siddiqi; Mark E Olah; Gary L Stiles; Dag K J E von Lubitz
Journal:  Drugs Future       Date:  1995-07       Impact factor: 0.148

4.  Effect of propentofylline (HWA 285) on extracellular purines and excitatory amino acids in CA1 of rat hippocampus during transient ischaemia.

Authors:  P Andiné; K A Rudolphi; B B Fredholm; H Hagberg
Journal:  Br J Pharmacol       Date:  1990-08       Impact factor: 8.739

5.  Essential role of adenosine, adenosine A1 receptors, and ATP-sensitive K+ channels in cerebral ischemic preconditioning.

Authors:  C Heurteaux; I Lauritzen; C Widmann; M Lazdunski
Journal:  Proc Natl Acad Sci U S A       Date:  1995-05-09       Impact factor: 11.205

6.  Modulation by purines of calcium-activated non-selective cation channels in the outer hair cells of the guinea-pig cochlea.

Authors:  T Van den Abbeele; P Tran Ba Huy; J Teulon
Journal:  J Physiol       Date:  1996-07-01       Impact factor: 5.182

7.  Release of endogenous adenosine and its metabolites by the activation of NMDA receptors in the rat hippocampus in vivo.

Authors:  Y Chen; D I Graham; T W Stone
Journal:  Br J Pharmacol       Date:  1992-07       Impact factor: 8.739

8.  Changes in extracellular adenosine levels and population spike amplitude during graded hypoxia in the rat hippocampal slice.

Authors:  J C Fowler
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-01       Impact factor: 3.000

9.  Block by N6-L-phenylisopropyl-adenosine of the electrophysiological and morphological correlates of hippocampal ischaemic injury in the gerbil.

Authors:  M R Domenici; A S de Carolis; S Sagratella
Journal:  Br J Pharmacol       Date:  1996-07       Impact factor: 8.739

10.  Sex differences in caffeine neurotoxicity following chronic ethanol exposure and withdrawal.

Authors:  Tracy R Butler; Katherine J Smith; Jennifer N Berry; Lynda J Sharrett-Field; Mark A Prendergast
Journal:  Alcohol Alcohol       Date:  2009-09-16       Impact factor: 2.826
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