Rhia Shah1, Supinda Bunyavanich2,3. 1. Division of Pulmonary Medicine, Department of Pediatrics. 2. Division of Allergy and Immunology, Department of Pediatrics. 3. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Abstract
PURPOSE OF REVIEW: Asthma is the most common chronic disease of childhood. Investigations of the lower and upper airway microbiomes have significantly progressed over recent years, and their roles in pediatric asthma are becoming increasingly clear. RECENT FINDINGS: Early studies identified the existence of upper and lower airway microbiomes, including imbalances in both associated with pediatric asthma. The infant airway microbiome may offer predictive value for the development of asthma in later childhood, and it may also be influenced by external factors such as respiratory viral illness. The airway microbiome has also been associated with the clinical course of asthma, including rates of exacerbation and level of control. Advances in -omics sciences have enabled improved identification of the airway microbiome's relationships with host response and function in children with asthma. Investigations are now moving toward the application of the above findings to explore risk modification and treatment options. SUMMARY: The airway microbiome provides an intriguing window into pediatric asthma, offering insights into asthma diagnosis, clinical course, and perhaps treatment. Further investigation is needed to solidify these associations and translate research findings into clinical practice.
PURPOSE OF REVIEW: Asthma is the most common chronic disease of childhood. Investigations of the lower and upper airway microbiomes have significantly progressed over recent years, and their roles in pediatric asthma are becoming increasingly clear. RECENT FINDINGS: Early studies identified the existence of upper and lower airway microbiomes, including imbalances in both associated with pediatric asthma. The infant airway microbiome may offer predictive value for the development of asthma in later childhood, and it may also be influenced by external factors such as respiratory viral illness. The airway microbiome has also been associated with the clinical course of asthma, including rates of exacerbation and level of control. Advances in -omics sciences have enabled improved identification of the airway microbiome's relationships with host response and function in children with asthma. Investigations are now moving toward the application of the above findings to explore risk modification and treatment options. SUMMARY: The airway microbiome provides an intriguing window into pediatric asthma, offering insights into asthma diagnosis, clinical course, and perhaps treatment. Further investigation is needed to solidify these associations and translate research findings into clinical practice.
Authors: Jonathan Thorsen; Jakob Stokholm; Morten Arendt Rasmussen; Martin Steen Mortensen; Asker Daniel Brejnrod; Mathis Hjelmsø; Shiraz Shah; Bo Chawes; Klaus Bønnelykke; Søren Johannes Sørensen; Hans Bisgaard Journal: Am J Respir Crit Care Med Date: 2021-07-15 Impact factor: 21.405
Authors: Markus Hilty; Conor Burke; Helder Pedro; Paul Cardenas; Andy Bush; Cara Bossley; Jane Davies; Aaron Ervine; Len Poulter; Lior Pachter; Miriam F Moffatt; William O C Cookson Journal: PLoS One Date: 2010-01-05 Impact factor: 3.240
Authors: Martin Depner; Markus J Ege; Michael J Cox; Sarah Dwyer; Alan W Walker; Lena T Birzele; Jon Genuneit; Elisabeth Horak; Charlotte Braun-Fahrländer; Hanna Danielewicz; Raina M Maier; Miriam F Moffatt; William O Cookson; Dick Heederik; Erika von Mutius; Antje Legatzki Journal: J Allergy Clin Immunol Date: 2016-07-27 Impact factor: 10.793
Authors: Jonathan Thorsen; Morten A Rasmussen; Johannes Waage; Martin Mortensen; Asker Brejnrod; Klaus Bønnelykke; Bo L Chawes; Susanne Brix; Søren J Sørensen; Jakob Stokholm; Hans Bisgaard Journal: Nat Commun Date: 2019-11-01 Impact factor: 14.919