Ole Jung1, Mike Barbeck2,3, L U Fan4, Fabian Korte4, Cuifeng Zhao5, Rumen Krastev4,5, Sven Pantermehl1, Xin Xiong6. 1. Clinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, Rostock, Germany. 2. BerlinAnalytix GmbH, Berlin, Germany. 3. Department of Ceramic Materials, Chair of Advanced Ceramic Materials, Institute for Materials Science and Technologies, Technical University Berlin, Berlin, Germany. 4. NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany. 5. Faculty of Applied Chemistry, Reutlingen University, Reutlingen, Germany. 6. BerlinAnalytix GmbH, Berlin, Germany; xin.xiong@nmi.de.
Abstract
BACKGROUND/AIM: The aim of this study was the conception, production, material analysis and cytocompatibility analysis of a new collagen foam for medical applications. MATERIALS AND METHODS: After the innovative production of various collagen sponges from bovine sources, the foams were analyzed ex vivo in terms of their structure (including pore size) and in vitro in terms of cytocompatibility according to EN ISO 10993-5/-12. In vitro, the collagen foams were compared with the established soft and hard tissue materials cerabone and Jason membrane (both botiss biomaterials GmbH, Zossen, Germany). RESULTS: Collagen foams with different compositions were successfully produced from bovine sources. Ex vivo, the foams showed a stable and long-lasting primary structure quality with a bubble area of 1,000 to 2,000 μm2 In vitro, all foams showed sufficient cytocompatibility. CONCLUSION: Collagen sponges represent a promising material for hard and soft tissue regeneration. Future studies could focus on integrating and investigating different additives in the foams.
BACKGROUND/AIM: The aim of this study was the conception, production, material analysis and cytocompatibility analysis of a new collagen foam for medical applications. MATERIALS AND METHODS: After the innovative production of various collagen sponges from bovine sources, the foams were analyzed ex vivo in terms of their structure (including pore size) and in vitro in terms of cytocompatibility according to EN ISO 10993-5/-12. In vitro, the collagen foams were compared with the established soft and hard tissue materials cerabone and Jason membrane (both botiss biomaterials GmbH, Zossen, Germany). RESULTS: Collagen foams with different compositions were successfully produced from bovine sources. Ex vivo, the foams showed a stable and long-lasting primary structure quality with a bubble area of 1,000 to 2,000 μm2 In vitro, all foams showed sufficient cytocompatibility. CONCLUSION: Collagen sponges represent a promising material for hard and soft tissue regeneration. Future studies could focus on integrating and investigating different additives in the foams.
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