| Literature DB >> 34410142 |
Enjing Jin1, Huayue Li1,2, Zengzhi Liu1, Fei Xiao1, Wenli Li1,2.
Abstract
Two new (1 and 2) along with six known (3-8) dixiamycins were isolated from the culture broth of a cold-seep-derived actinomycete, Streptomyces olivaceus OUCLQ19-3. Structures of the isolated compounds were elucidated based on extensive MS and NMR spectroscopic analyses together with ECD calculations. In the antibacterial test, compounds 1-8 exhibited notable growth inhibitions against a panel of multi-drug-resistant (MDR) strains with MIC values of 0.78-6.25 μg/mL, among which 1, 2, and 5-7 were more potent than the positive control tetracycline.Entities:
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Year: 2021 PMID： 34410142 DOI： 10.1021/acs.jnatprod.1c00411
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050