Derek D George1, Nicholas K Baer1, Jean M Berliner2, Jacqueline Jones3, Benzi M Kluger4. 1. Department of Neurology, School of Medicine University of Colorado-Anschutz Medical Campus Aurora Colorado USA. 2. Rehabilitation Sciences Program School of Medicine, University of Colorado-Anschutz Medical Campus Aurora Colorado USA. 3. College of Nursing University of Colorado-Anschutz Medical Campus Aurora Colorado USA. 4. Departments of Neurology and Medicine School of Medicine, University of Rochester Medical Center Rochester New York USA.
Abstract
BACKGROUND: Fatigue is one of the most prevalent non-motor symptoms of Parkinson's disease (PD). Research is hampered by imprecise terminology and the lack of case definition criteria. OBJECTIVES: To elicit the experiences of persons living with PD-related fatigue and provide ecological validation for case definition criteria. METHODS: Qualitative interviews were conducted with 22 individuals and 4 focus groups, and analyzed using an inductive qualitative method. RESULTS: Six core themes emerged: (i) difficulty initiating and completing important tasks; (ii) desire for others to understand their fatigue experience; (iii) heterogeneity of experiences and descriptions of fatigue; (iv) complex relationships with other non-motor symptoms; (v) variable self-management strategies; and (vi) general alignment with proposed case definition criteria. CONCLUSIONS: PD-related fatigue impacts function, is subjectively distinguishable from other non-motor symptoms, has heterogeneous descriptions, and may be mitigated by various self-management strategies. Proposed case definition criteria appear ecologically valid and warrant further optimization and testing.
BACKGROUND: Fatigue is one of the most prevalent non-motor symptoms of Parkinson's disease (PD). Research is hampered by imprecise terminology and the lack of case definition criteria. OBJECTIVES: To elicit the experiences of persons living with PD-related fatigue and provide ecological validation for case definition criteria. METHODS: Qualitative interviews were conducted with 22 individuals and 4 focus groups, and analyzed using an inductive qualitative method. RESULTS: Six core themes emerged: (i) difficulty initiating and completing important tasks; (ii) desire for others to understand their fatigue experience; (iii) heterogeneity of experiences and descriptions of fatigue; (iv) complex relationships with other non-motor symptoms; (v) variable self-management strategies; and (vi) general alignment with proposed case definition criteria. CONCLUSIONS: PD-related fatigue impacts function, is subjectively distinguishable from other non-motor symptoms, has heterogeneous descriptions, and may be mitigated by various self-management strategies. Proposed case definition criteria appear ecologically valid and warrant further optimization and testing.
Authors: Winona Tse; Yiming Liu; Gabriele M Barthlen; Thomas D Hälbig; Sonia V Tolgyesi; Jean-Michel Gracies; C Warren Olanow; William C Koller Journal: Parkinsonism Relat Disord Date: 2005-08 Impact factor: 4.891
Authors: Ziad S Nasreddine; Natalie A Phillips; Valérie Bédirian; Simon Charbonneau; Victor Whitehead; Isabelle Collin; Jeffrey L Cummings; Howard Chertkow Journal: J Am Geriatr Soc Date: 2005-04 Impact factor: 5.562
Authors: Jean M Berliner; Benzi M Kluger; Daniel M Corcos; Victoria S Pelak; Robyn Gisbert; Cynthia McRae; Christine C Atkinson; Margaret Schenkman Journal: Physiother Theory Pract Date: 2018-07-06 Impact factor: 2.279
Authors: Joseph H Friedman; Richard G Brown; Cynthia Comella; Carol E Garber; Lauren B Krupp; Jau-Shin Lou; Laura Marsh; Lillian Nail; Lisa Shulman; C Barr Taylor Journal: Mov Disord Date: 2007-02-15 Impact factor: 10.338
Authors: Sang Soo Cho; Kelly Aminian; Crystal Li; Anthony E Lang; Sylvain Houle; Antonio P Strafella Journal: Hum Brain Mapp Date: 2016-08-29 Impact factor: 5.038