| Literature DB >> 34396507 |
Camille Boisson1,2, Céline Renoux1,2,3, Elie Nader1,2, Alexandra Gauthier1,2,4, Solène Poutrel1,2,5, Minke Rab6, Romain Fort1,2,5, Yves Bertrand4, Emeric Stauffer1,2,7, Giovanna Cannas5, Kamila Kebaili1,2,4, Emilie Virot1,2,5, Arnaud Hot5, Vivien Sheehan8, Eduard van Beers9, Richard van Wijk6, Philippe Joly1,2,3, Philippe Connes1,2.
Abstract
The present study tested the impact of α-thalassaemia on oxygen gradient ektacytometry in sickle cell anaemia (SCA). Three SCA groups were compared: (i) no α-thalassaemia (four α-genes, n = 62), (ii) silent α-thalassaemia (three α-genes, n = 35) and (iii) homozygous α-thalassaemia (two α-genes, n = 12). Red blood cell (RBC) deformability measured in normoxia was not different between the three groups. The lowest RBC deformability reached at low oxygen partial pressure (pO2 ) was greater and the pO2 at which RBC started to sickle was lower in the two α-genes group compared to the other groups. Our present study showed an effect of α-thalassaemia on oxygen gradient ektacytometry in SCA.Entities:
Keywords: red blood cell deformability; sickle cell disease; sickling; α-thalassaemia
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Year: 2021 PMID： 34396507 DOI： 10.1111/bjh.17777
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998