Taimoor Khalid Janjua1, Muhammad Ali Yousuf2, Muhammad Talha Iqbal1, Shahbaz Mustafa Memon3, Aziz Abdullah2, Naveen Faridi4, Muhammad Irfan5. 1. Liaquat National Medical College, Liaquat National Hospital, Karachi, Pakistan. 2. Urology Department, Liaquat National Hospital, Karachi, Pakistan. 3. Surgery Department, Sherwood Forest Hospitals, NHS Trust, Nottinghamshire, United Kingdom. 4. Pathology Department, Liaquat National Hospital, Pakistan. 5. Biostatistics Department, Liaquat National Hospital, Karachi, Pakistan.
Abstract
INTRODUCTION: incidental prostate cancer findings reflect the great burden of prostatic cancer across the globe. Our 10 year retrospective analysis aimed to identify the incidence and clinic-pathologic features of prostate cancer incidentally detected in patients undergoing transurethral resection of the prostate (TURP) for benign prostatic hyperplasia (BPH), and to estimate the clinical value of pathologic review of all TURP specimens. METHODS: after excluding patients with a known diagnosis of prostate cancer prior to TURP a total of 2,386 men (ages 25-98) were identified by pathology (TURP) specimens. Yearly incidences, Gleason score, grade, pathologic stage were recorded for all incidental prostate cancer patients. RESULTS: a total of 256 (10.7%) patients were found to have prostate cancer. Mean Age was 68.51±9.22 years. T1a and T1b stage prostatic carcinoma was found in 9.9% and 90.1% of these patients respectively. Forty-nine percent (49%) patients had higher Gleason scores (>7). After subtracting average incidences between 5-year intervals, a statistical rise of almost 4% was found. CONCLUSION: our analysis concludes that a large proportion (10.7%) of patients had incidental prostate cancer and the incidence was increasing in recent years in Pakistan and in comparison, to Asian countries. In Pakistan there is a scarcity of updated national cancer registries. The growing incidence of high Gleason scores requires keen and prompt attention. The diverse ethnic and socioeconomic background of patients propels their propensity towards loss of follow up with already limited tertiary healthcare institutes in Pakistan. This pathologic review of TURP specimens is valuable for Asiatic and non-Asiatic populations. Copyright: Taimoor Khalid Janjua et al.
INTRODUCTION: incidental prostate cancer findings reflect the great burden of prostatic cancer across the globe. Our 10 year retrospective analysis aimed to identify the incidence and clinic-pathologic features of prostate cancer incidentally detected in patients undergoing transurethral resection of the prostate (TURP) for benign prostatic hyperplasia (BPH), and to estimate the clinical value of pathologic review of all TURP specimens. METHODS: after excluding patients with a known diagnosis of prostate cancer prior to TURP a total of 2,386 men (ages 25-98) were identified by pathology (TURP) specimens. Yearly incidences, Gleason score, grade, pathologic stage were recorded for all incidental prostate cancer patients. RESULTS: a total of 256 (10.7%) patients were found to have prostate cancer. Mean Age was 68.51±9.22 years. T1a and T1b stage prostatic carcinoma was found in 9.9% and 90.1% of these patients respectively. Forty-nine percent (49%) patients had higher Gleason scores (>7). After subtracting average incidences between 5-year intervals, a statistical rise of almost 4% was found. CONCLUSION: our analysis concludes that a large proportion (10.7%) of patients had incidental prostate cancer and the incidence was increasing in recent years in Pakistan and in comparison, to Asian countries. In Pakistan there is a scarcity of updated national cancer registries. The growing incidence of high Gleason scores requires keen and prompt attention. The diverse ethnic and socioeconomic background of patients propels their propensity towards loss of follow up with already limited tertiary healthcare institutes in Pakistan. This pathologic review of TURP specimens is valuable for Asiatic and non-Asiatic populations. Copyright: Taimoor Khalid Janjua et al.
Authors: J Joy Lee; I-Chun Thomas; Rosalie Nolley; Michelle Ferrari; James D Brooks; John T Leppert Journal: Prostate Date: 2014-10-18 Impact factor: 4.104
Authors: Dae Keun Kim; Sang Jin Kim; Hong Sang Moon; Sung Yul Park; Yong Tae Kim; Hong Yong Choi; Tchun Yong Lee; Hae Young Park Journal: Korean J Urol Date: 2010-05-19
Authors: Changhee Yoo; Cheol Young Oh; Se Joong Kim; Sun Il Kim; Young Sig Kim; Jong Yeon Park; Do Hwan Seong; Yun Seob Song; Won Jae Yang; Hyun Chul Chung; In Rae Cho; Sung Yong Cho; Sang Hyeon Cheon; Sungjoon Hong; Jin Seon Cho Journal: Korean J Urol Date: 2012-06-19