Christophe Habas1. 1. Service de NeuroImagerie, Centre Hospitalier National des 15-20, 28, rue de Charenton, 75012, Paris, France. chabas@15-20.fr.
Abstract
BACKGROUND: Basal ganglia and cerebellum are structurally and functionally connected in animals. In humans, tractography and seed-based functional connectivity have confirmed this cerebellar-striatal relation. Independent component analysis (ICA) showed that both cerebellum and basal ganglia take part in distinct intrinsic networks. METHODS: Probabilistic ICA analysis was applied to the brain images of 15 healthy volunteers during the resting state and using a 3 T MRI. RESULTS: A spatial map corresponding to dorsal and ventral basal ganglia circuits was also found to be in functional coherence with crus 2, especially with its vermal region. CONCLUSION: It is speculated that such cerebellar-basal ganglionic rsFC could reflect structural interconnections traced in animals and explain reward-based activity detected in the cerebellum.
BACKGROUND: Basal ganglia and cerebellum are structurally and functionally connected in animals. In humans, tractography and seed-based functional connectivity have confirmed this cerebellar-striatal relation. Independent component analysis (ICA) showed that both cerebellum and basal ganglia take part in distinct intrinsic networks. METHODS: Probabilistic ICA analysis was applied to the brain images of 15 healthy volunteers during the resting state and using a 3 T MRI. RESULTS: A spatial map corresponding to dorsal and ventral basal ganglia circuits was also found to be in functional coherence with crus 2, especially with its vermal region. CONCLUSION: It is speculated that such cerebellar-basal ganglionic rsFC could reflect structural interconnections traced in animals and explain reward-based activity detected in the cerebellum.
Authors: A Di Martino; A Scheres; D S Margulies; A M C Kelly; L Q Uddin; Z Shehzad; B Biswal; J R Walters; F X Castellanos; M P Milham Journal: Cereb Cortex Date: 2008-04-09 Impact factor: 5.357