Literature DB >> 34388528

Betulinic acid in the treatment of tumour diseases: Application and research progress.

Wenkai Jiang1, Xin Li2, Shi Dong3, Wence Zhou4.   

Abstract

Betulinic acid (BA) is a pentacyclic triterpene compound that can be obtained by separation, chemical synthesis and biotransformation from birch. BA has antitumour activity, and its mechanisms of action mainly include the induction of mitochondrial oxidative stress; the regulation of specificity protein transcription factors, and the inhibition of signal transducer and activator of transcription 3 and nuclear factor-κB signalling pathways. In addition, BA can increase the sensitivity of cancer cells to other chemotherapy drugs. Recent studies have shown that BA plays an anticancer role in several kinds of tumour diseases. In this article, the anticancer mechanism of BA and its application in the treatment of tumour diseases are reviewed.
Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Entities:  

Keywords:  Apoptosis; Betulinic acid; Cell cycle; Chemotherapy; Tumour

Mesh：

Substances：

Year:  2021        PMID： 34388528     DOI： 10.1016/j.biopha.2021.111990

Source DB:  PubMed          Journal:  Biomed Pharmacother        ISSN： 0753-3322            Impact factor:   6.529


  7 in total

Review 1.  Phytochemicals for the Prevention and Treatment of Renal Cell Carcinoma: Preclinical and Clinical Evidence and Molecular Mechanisms.

Authors:  Essa M Bajalia; Farah B Azzouz; Danielle A Chism; Derrek M Giansiracusa; Carina G Wong; Kristina N Plaskett; Anupam Bishayee
Journal:  Cancers (Basel)       Date:  2022-07-04       Impact factor: 6.575

Review 2.  Anti-Inflammatory Activities of Betulinic Acid: A Review.

Authors:  José Fernando Oliveira-Costa; Cássio Santana Meira; Maria Vitória Gomes das Neves; Bruna Padilha Zurita Claro Dos Reis; Milena Botelho Pereira Soares
Journal:  Front Pharmacol       Date:  2022-05-23       Impact factor: 5.988

Review 3.  Therapeutic Potential of Certain Terpenoids as Anticancer Agents: A Scoping Review.

Authors:  Sareh Kamran; Ajantha Sinniah; Mahfoudh A M Abdulghani; Mohammed Abdullah Alshawsh
Journal:  Cancers (Basel)       Date:  2022-02-22       Impact factor: 6.639

4.  The Influence of Betulin and Its Derivatives EB5 and ECH147 on the Antioxidant Status of Human Renal Proximal Tubule Epithelial Cells.

Authors:  Celina Kruszniewska-Rajs; Barbara Strzałka-Mrozik; Magdalena Kimsa-Dudek; Agnieszka Synowiec-Wojtarowicz; Elwira Chrobak; Ewa Bębenek; Stanisław Boryczka; Stanisław Głuszek; Joanna Magdalena Gola
Journal:  Int J Mol Sci       Date:  2022-02-25       Impact factor: 5.923

Review 5.  The Role of m6A RNA Methylation in Cancer: Implication for Nature Products Anti-Cancer Research.

Authors:  Na Song; Kai Cui; Ke Zhang; Jie Yang; Jia Liu; Zhuang Miao; Feiyue Zhao; Hongjing Meng; Lu Chen; Chong Chen; Yushan Li; Minglong Shao; Jinghang Zhang; Haijun Wang
Journal:  Front Pharmacol       Date:  2022-06-16       Impact factor: 5.988

6.  Glycosylated Zein Composite Nanoparticles for Efficient Delivery of Betulinic Acid: Fabrication, Characterization, and In Vitro Release Properties.

Authors:  Fei Peng; Yu Jin; Kunhua Wang; Xiaojing Wang; Yaqing Xiao; Huaide Xu
Journal:  Foods       Date:  2022-08-26

7.  Synthesis and Biological Evaluation of Novel Allobetulon/Allobetulin-Nucleoside Conjugates as AntitumorAgents.

Authors:  Yanli Wang; Xiaowan Huang; Xiao Zhang; Jingchen Wang; Keyan Li; Guotao Liu; Kexin Lu; Xiang Zhang; Chengping Xie; Teresa Zheng; Yung-Yi Cheng; Qiang Wang
Journal:  Molecules       Date:  2022-07-25       Impact factor: 4.927
  7 in total

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